摘要
目的了解2型糖尿病患者中踝臂血压指数(ABI)与尿白蛋白与肌酐比值(UACR)的相关性。方法收集自2009-01-2011-01在我院内分泌科住院的2型糖尿病患者共469例,测定ABI及其他相关指标。选取同期在我院门诊体检者38例为正常对照组。研究2型糖尿病患者ABI异常与UACR的相关性。结果 469例2型糖尿病患者尿蛋白异常率62.7%,ABI异常率42.6%。临床蛋白尿组、微量蛋白尿组、尿蛋白正常组3组患者的ABI异常率分别为41.4%、23.2%、14.9%。ABI≤0.9组、ABI>1.3组、ABI>0.9～1.3组蛋白尿发生率分别是45.2%、31.5%、22.7%(P<0.05)。多因素回归分析结果显示,糖尿病发生下肢动脉病变的可能影响因素是年龄、血压、空腹血糖、总胆固醇、低密度脂蛋白胆固醇、UACR、肾小球滤过率和糖化血红蛋白(P<0.05)。结论糖尿病患者中ABI异常与UACR增高伴发率高,ABI异常还受年龄、血糖、血脂、血压等因素的影响。
Objective To investigate the relationship between ankle-brachial index （ABI） and urinary albumin to creatinine ratio （UACR） in patients with type 2 diabetes mellitus. Methods From January 2009 to January 2011, a total of 469 type 2 diabetic patients were enrolled. The ABI, UACR and other related indexes were measured. Thirty-eight healthy subjects served as controls. Results In all 469 patients, the prevalence of urinary protein was 62.7% ; the prevalence of abnormal ABI 42.6%. Prevalence of abnormal ABI was 41.4%, 23.2% and 14.9% in the clinical, micro-and normal albuminuria. Prevalence of urinary protein was 45.2%, 31.5% and 22.7% in the patients with ABI≤0.9, ABI〉1.3, and ABI〈0.9-1.3. Multiple variables analysis showed that the influence factors for the occurrence of lower extremity arterial lesions in diabetes mellitus＇patients were age, blood pressure, fasting plasma glucose, total cholesterol, low density lipoprotein-cholesterol, HbAIC, UACR and GFR （P%0.05 ）. Conclusions The diabetes mellitus patients with abnormality of ABI usually have a high prevalence of increased ACR. ABI is also affected by age, blood glucose, blood lipids, and blood pressure.
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2011年第11期1075-1079,共5页
Chinese Journal of Hypertension
关键词
糖尿病
尿白蛋白与肌酐比值
下肢动脉病变
踝臂血压指数
Diabetes
Urinary albumin to creatinine ratio
Peripheral artery disease
Ankle-brachial index
