摘要
目的:探讨GnRH拮抗剂(GnRH-ant)与激动剂(GnRH-a)联合应用对环磷酰胺(CTX)化疗中卵巢功能保护作用。方法:选取36只8～9周成年雌性Balb/c小鼠,随机分为对照组、CTX组、GnRH-ant+GnRH-a组和GnRH-ant+GnRH-a+CTX组,每组各9只。用药后比较各组小鼠体重、子宫和卵巢湿重、各级卵泡数量的变化,以及促卵泡生成素(FSH)、雌二醇(E2)水平。结果:与GnRH-ant+GnRH-a+CTX组比较,CTX组小鼠子宫及卵巢湿重显著减轻,卵泡总数减少,血清E2浓度下降及FSH浓度升高,差异均有统计学意义(均P<0.05)。结论:GnRH-ant和GnRH-a联合应用对环磷酰胺化疗诱导的小鼠卵巢损伤具有一定的保护作用。
Objective：To explore the protection of GnRH antagonist and agonist for ovarian function in Cytoxan chemotherapy.Methods：36 eugamic female Balb/c mice（aged from 8 to 9 weeks） were randomly divided into four groups,control group,Cytoxan（CTX） group,GnRH-ant＋GnRH-a group and GnRH-ant＋GnRH-a＋CTX group,with 9 in each group.The body weight change,uterus and ovary wet weight,the numbers of the follicle,the serum level of FSH and E2 were all observed and compared after administration.Results：Compared with GnRH-ant＋GnRH-a＋CTX group,CTX group produced a significant reduction in the total number of follicle and the weights of CTX group were lower than those of GnRH-ant＋GnRH-a＋CTX group,and E2 levels significantly decreased,FSH levels significantly increased,there were significant differences（all P0.05）.Conclusion：Application of GnRH-ant and GnRH-a can contribute to prevent the Cytoxan-induced ovarian damage in mice.
出处
《中国医药导报》
CAS
2011年第36期26-28,共3页
China Medical Herald
