摘要
MicroRNA(miRNA)是一类长21～25个核苷酸的小分子非编码RNA,通过与特定mRNA 3'UTR结合抑制蛋白质表达参与生物的发育、代谢及肿瘤的发生、发展等生命现象。近年来,越来越多的研究显示miRNA与肺癌的诊断、治疗关系密切,可作为肺癌早期诊断的生物标志物,还可能成为肺癌靶向治疗的有效靶点。本文结合国内外最新报道,综述miRNA在肺癌诊断、治疗方面的研究进展。
MicroRNA（miRNA） is a class of about 21 to 25 nucleotide small non-coding RNA,which binding with specific mRNA 3＇UTR to inhibit expression of the protein,involved in organisms＇ development,metabolism,tumorigenesis and other biological phenomena.In recent years,a growing number of studies have shown that miRNA is correlated with diagnosis and treatment of lung cancer closely,which not only can be used as biomarker for lung cancer disgnosis,but also could be used as effective target for lung cancer therapy.This paper reviews research progress of miRNA in lung cancer diagnosis and therapy from the latest articles home and abroad.
出处
《中国医药导报》
CAS
2011年第36期7-10,共4页
China Medical Herald
基金
国家自然科学基金(No.30973477)
江苏省自然科学基金(No.BK2010590)
江苏省"六大人才高峰"计划(09-B1-021)
关键词
MIRNA
肺癌
诊断
靶向治疗
miRNA
Lung cancer
Diagnosis
Targeted therapy
