摘要
目的探讨血清抗酒石酸酸性磷酸酶5b（TRACP5b）预测淋巴结阴性乳腺癌骨转移的临床价值。方法采用酶联免疫吸附法（ELISA）检测18例健康女性、26例淋巴结阴性乳腺癌的血清TRACP5h水平。结果乳腺癌组血清TRACPSb水平为（3．85±0．85）U／L较健康组（2．08±O．84）U／L明显升高，差异有统计学意义（P〈0．05）；血清TRACP5b预测淋巴结阴性乳腺癌骨转移的敏感性为42．31％，特异性为94．44％。结论血清TRACPSb在早期预测乳腺癌骨转移中的敏感性和特异性良好，可作为诊断乳腺癌骨转移的血清标记物之一。
Objective To study the value of serum tartrate-resistant acid phosphatase 5b （TRACPSb） in bone metastasis in early breast cancer patients with negative axillary lymph nodes. Methods The serum level of TRACPSb was determined by enzyme-linked immumosorbent assay （ELISA） in 26 breast cancer patients and 18 healthy female adults. Results The serum level of TRACPSb was （3.85±0.85 ） U/L in the group of breast cancer patients and （2.08 ± 0.84） U/L in the control group. The difference had statistical significance （ P 〈 0.05）. The sensitivity was 42.31% and the specificity was 94.44% for TRACPSb in predicting bone metastasis of breast cancer with negtive axillary lymph nodes. Conclusions TRACPSb has higher sensitivity and specificity in breast cancer patients than in healthy female adults. TRACPSb is a useful serum marker to predict bone metas- tasis in breast cancer patients.
出处
《中华内分泌外科杂志》
CAS
2011年第6期377-379,共3页
Chinese Journal of Endocrine Surgery
