摘要
目的 探讨Claassen分级与动脉瘤性蛛网膜下腔出血（aSAH）后认知功能损害的关系.方法 对40例行血管内治疗的颅内动脉瘤破裂患者进行前瞻性研究,分析Claassen分级、动脉瘤部位、年龄与aSAH后认知功能损害的相关性.结果 多因素分析仅Claassen分级进入回归方程（P＜0.01）；Classeen分级与总智商量表分存在负相关,两者Spearman相关系数为-0.398（P＜0.01）；前交通动脉瘤患者与其他部位动脉瘤患者在总智商、言语智商、操作智商上差异无统计学意义（P＞0.05）.结论 认知功能损害广泛存在于颅内动脉瘤破裂患者,SAH是破裂动脉瘤患者发生认知功能损害的主要原因.Claassen分级是预测患者发生认知功能损害的危险因素,分级越高认知损害发生的危险性越大；动脉瘤的部位与患者认知损害的发生及程度无明显相关性.
Objective To study the relationship between Claassen scale,age of patients,anatomical location of aneurysms and the cognitive disorders in patients with aneurysmal subarachnoid hemorrhage （aSAH） after endovascular treatment.Methods 40 patients underwent endovascular coiling for aSAH were studied.The preoperative and postoperative course in all patients was uneventful.CT,cerebral angiography （CAG）,neuropsychological examination （Wechsler adult intelligence scale,WAIS - R） were used for examination.Results After logistic procedure analysis,it was found that Claassen Scale was a risk factor for cognition disorders （ P 〈0.01 ）.The level of Claassen Scale was negatively correlated with the score of total intelligence quotient （ r =- 0.398,P 〈 0.01 ）.According to anatomical location of aneurysms,there was no significantly statistical difference between the anterior communicating aneurysm （Acoa） group and non- Acoa group in total intelligence quotient,verbal intelligence quotient and performance intelligence quotient（ P 〉0.05 ）.Conclusions Despite good outcomes after aSAH,cognition disorders in patients are still common,suggesting that the common impairments of brain after treatment of ruptured aneurysms may be due to SAH itself.Claassen Scale may account for predictive value for cognition disorders.
出处
《中华神经外科杂志》
CSCD
北大核心
2011年第12期1205-1208,共4页
Chinese Journal of Neurosurgery
基金
浙江省卫生厅资助项目（2009A142）
