摘要
以4-氯苯基乙酮和环丙胺为原料,通过两步反应合成1-(4-氯苯基)-2-环丙基乙酮。首先利用重氮化溴代反应一步合成溴代环丙烷,然后将溴代环丙烷和4-氯苯基乙酮在碱性条件下反应得1-(4-氯苯基)-2-环丙基乙酮。讨论了影响反应产率的各种因素,找到了达到最高产率的反应条件。实验中得到的1-(4-氯苯基)-2-环丙基乙酮的最高产率为82.8%。
Starting from the compound 4 - chlorophenylethanone and cyclopropylamine, got 1 - （4 - chlorophenyl） - 2 - cyclopropylethanone via two reactions. First step, making use of diazotization reaction to get bromocyclopropane. Then put bromocyclopropane and 4 - chlorophenylethanone under the alkaline condition, could get 1 - （4 - chlorophenyl） - 2 - cyclopropylethanone. A variety of factors that impacted the yield were discussed. The best condition of this reaction was found, giving the highest yield of 82.8%.
出处
《山东化工》
CAS
2011年第11期16-20,共5页
Shandong Chemical Industry
