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他汀类药物的多效性及其在心血管疾病中的应用 被引量：3

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摘要 他汀类药物(statins)通过抑制内源性胆固醇合成限速酶还原酶,使细胞内胆固醇合成减少,是治疗动脉粥样硬化(AS)的基本药物。研究表明,他汀类药物还存在着非胆固醇依赖的多效性,包括改善血管内皮功能,抑制血管平滑肌增殖,促进血管新生,抗炎、抗氧化以及减轻血管和心肌重构等。这种"多效性"在急性心肌梗死、心肌肥大以及心力衰竭等心血管疾病的防治中发挥着重要作用。
作者 毕学苑 贺熙 臧伟进
机构地区 西安交通大学医学院药理学系
出处 《心脏杂志》 CAS 2011年第6期804-806,810,共4页 Chinese Heart Journal
基金 国家自然科学基金重点项目资助(30930105 30873058) 国家重点基础研究发展973计划项目资助(2007CB512005) 中华医学基金会杰出教授奖资助(F510000/G16916404)
关键词 他汀类药物 多效性 心血管疾病
分类号 R972.6 [医药卫生—药品]
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二级参考文献47

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共引文献29

同被引文献34

  • 1马维军.两种剂量阿托伐他汀用于老年血脂正常冠心病患者的效果比较[J].中国老年学杂志,2015,35(1):114-115. 被引量：31
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心脏杂志
2011年 第6期

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