摘要
目的:研究黄腐酸钠对小鼠胃肠运动及胃溃疡的影响;方法:以黑色炭末为指示剂,通过测定正常小鼠、复方地芬诺酯所致的小鼠小肠推进抑制、生大黄致小鼠脾虚腹泻模型的炭末推进百分率,观察黄腐酸钠对小鼠肠运动的影响;采用无水乙醇灌胃造成小鼠急性胃溃疡,观察黄腐酸钠预防给药对胃黏膜损伤的保护作用,计算溃疡指数和溃疡抑制率。结果:黄腐酸钠灌胃对正常小鼠、生大黄致小鼠腹泻模型均有一定抑制胃肠运动作用,对复方地芬诺酯所致小鼠胃肠运动减弱有明显的协同作用;对无水乙醇引起的小鼠胃黏膜损伤有保护作用,高剂量黄腐酸钠与阳性对照药物雷尼替丁的溃疡指数和溃疡抑制率无显著性差异。结论:在剂量范围内,黄腐酸钠的急性毒性很小,具有止泻、抗胃溃疡、保护胃黏膜损伤的作用。
Objective： To research the effects of Na-FA on gastrointestinal movement and gastrieulcer in mice. Methods： Using charcoal powder as an indicator, the effects of FA-Na on bowel movement of mice was evaluated by determining the propulsive percent-age of charcoal powder in normal mice, inhibition of small intestinal propulsion model induced by Compound Diphenoxylate and spleen asthenia and diarrhea model caused by Rheum officinale Baill ;The acute gastric ulcer model was induced by intragastric alcohol given o- rally ,the protective effect of FA-Na given ahead on gastric injury was evaluated ,the ulcer index and the inhibition ratio of ulcer was calculated. Results：FA-Na （intragastric administration） had inhibit effect on normal mice and diarrhea model caused by Rheum officinale, significantly synergetic effect of gastrointestinal asynersis induced by Compound Diphenoxylate, and protective effect on mice gastric mucosal injury cause by dehydrated alcohol. Compared with the positive control drug Ranitidine, the ulcer index and ulcer inhibition ratio large doses of FA-Na had no significant difference. Conclusion： The acute toxicity of FA-Na is very low,it has the effects of antidiarrheal and anti-gastric ulcer.
出处
《中药材》
CAS
CSCD
北大核心
2011年第10期1565-1569,共5页
Journal of Chinese Medicinal Materials
基金
企业联合开发项目(KKK0200826106)
校人才培养基金(KK20200726038)
关键词
黄腐酸钠
胃肠运动
脾虚
胃溃疡
FA-Na
Gastrointestinal movement
Spleen asthenia
Gastric ulcer
