摘要
目的探讨不良孕产史与外周血染色体异常的关系。方法对前来遗传咨询的1 648例有不良孕产史夫妇进行外周血淋巴细胞培养、染色体检查,G显带进行核型分析。结果 1 648例有不良孕产史夫妇查出染色体异常的核型77例,异常检出率为4.67%。其中常染色体异常23例(29.87%),性染色体异常54例(70.13%);染色体数目异常38例(49.35%),结构异常39例(50.65%)。1 648例中检出染色体多态性变异122例,检出率为7.40%。结论染色体异常与不良孕产史发生有关,遗传咨询与产前诊断在临床治疗及指导优生优育中意义重大。
ObjectiveTo investigate the adverse pregnancy history and the relationship between chromosome abnormalities in peripheral blood.Methods1 648 cases of adverse pregnancy history of genetic counseling couples who have questions about peripheral blood lymphocyte culture for chromosome,G-banding karyotype analysis.Results1 648 examples have bad are pregnant produce Mr.and Mrs.Shi to find out the chromosome unusual nuclear type 77 examples,the unusual detection rate is 4.67%.And euchromosome exceptionally 23 examples（29.87%）,sex chromosome exceptionally 54 examples（70.13%）;Chromosome number exceptionally 38 examples（49.35%）,textural anomaly 39 examples（50.65%）.in 1 648 examples picks out the chromosome polymorphism variation 122 examples,the detection rate is 7.40%.ConclusionChromosome abnormalities and adverse pregnancy history happens is related to genetic counseling and prenatal diagnosis in the clinical treatment and advice of great significance in prenatal and postnatal care.
出处
《实用临床医学（江西）》
CAS
2011年第9期64-66,共3页
Practical Clinical Medicine
关键词
遗传咨询
核型分析
染色体异常
优生优育
genetic counseling
karyotype analysis
chromosome abnormalities
prenatal and postnatal care
