2Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics--2011 update: a report from the American Heart Association [ J]. Circulation, 2011,123 (4) :18-209.
3Dawson J, Lees KR, Weir C J, et al. Baseline serum urate and 90-day functional outcomes following acute ischemic stroke [ J ]. Cerebrovasc Dis ,2009,28 (2) :202-203.
4Kim SY, Guevara JP, Kim KM,et al. Hyperurieemia and risk of stroke: a systematic review and meta-analysis[ J]. Arthritis Rheum,2009,61 (7) :885-892.
5Becket MA, Schumacher HR Jr, Wortmann RL, et al. Febuxostat compared with allopurinol in patients with hyperurieemia and gout [ J ]. N Engl J Med, 2005,353 (23) :2450-2461.
6Yu MA, S6nchez-Lozada LG, Johnson RJ, et al. Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction [J ]. J Hypertens ,2010,28 (6) : 1234-1242.
7Butler R, Morris AD, Belch JJ, et al. Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension[ J ]. Hypertension ,2000,35 ( 3 ) :746-751.
8Kang DH,Nakagawa T,Feng L, et al. A role for uric acid in the progression of renal disease [ J ]. J Am Soe Nephrol,2002,13 (12) :2888-2897.
9Kanbay M, Yilmaz M1, Sonmez A, et al. Serum uric acid level and endothelial dysfunction in patients with nondia- betic chronic kidney disease [ J ]. Am J Nephrol,2011,33 (4) :298-304.
10Sakr SA, Abbas TM, Amer MZ, et al. Microvascular angina. The possible role of inflammation, uric acid, and endothelial dysfunction [ J ]. Int Heart J, 2009,50 ( 4 ) : 407-419.
7Andrew J. Luk,Peter A. Simkin. Epidemiology of Hyperuricemia and Gout. The American Journal of Managed care ,2005:435-442.
8Sarti C ,Rastenyte D,Cepaitis Z.International trends in mortality from stroke, 1968 to 1994 J. Stroke,2000,31 (7) : 1588-1601.
9Yanyan Zhu, Bhavik J.Pandya,et al.Comorbidities of Gout and Hy- peruricemia in the US General Population:NHANES 2007-2008. The American Journal of Medicine, 2012,125 (7) : 679-687.
10Kim SY, Guevara JP, Kim KM, et al. Hyperuricemia and risk of stroke:a systematic review and meta-analysis: Arthritis & Rheuma- tism(Arthritis Care & Research), 2009,61 : 885-892.
