摘要
目的:比较两种a-受体阻滞剂在嗜铬细胞瘤术前准备中的应用疗效。方法:经病理确诊的93例功能性嗜铬细胞瘤患者,根据术前药物准备情况分为甲磺酸多沙唑嗪控释片(DOX)组26例和酚苄明(PXB)组67例。比较两组在围手术期对循环的影响。结果:术前降压有效率在DOX组为73.1%,在PXB组为86.6%,差异无统计学意义。副作用发生率在DOX组为23.1%,其中术中收缩压(≥160mmHg)1mmHg=0.133kpa、心率(≥100次/min)不稳定发生率分别为19.2%和11.5%;在PXB组为59.7%,其中术中收缩压(≥160mmHg)、心率(≥100/min)不稳定发生率分别为49.3%和41.8%,差异均有统计学意义。结论:DOX在围手术期具有良好的耐受性及降压扩容效果,术中能够更好地稳定血流动力学变化,是嗜铬细胞瘤术前准备的理想药物。
Objective To compare the effects of DOX and PXB in preoperative preparation of pheochomocytoma.Methods A total of 93 patients with functional pheochromocytoma were divided into two groups according to premedication：26 patients in the DOX group and 67 patients in the PXB group.Results Preoperative hypertension was controlled well in 73.1% of patients in the DOX group and 86.6% in the PXB group;The rate of side effects of two groups was respectively 23.1% and 59.7%. During the operation,systolic pressure steeply rise to 160 mmHg occurred respectively in 19.2% of patients in the DOX group and 49.3% in the PXB group,the heart rate abruptly increase to 100 occurred respectively in 11.5% of patients in the DOX group and 41.8% in the PXB group.There was no statistical difference between two groups in antihypertensive effect,but significant differences in the rate of side effects and haemodynamics instability.Conclusion Before the operation for pheochromocytoma,DOX and PXB have almost the same antihypertensive effect,but side effects and blood flow dynamics more stable.So,we think DOX can be the best drug in preoperative preparation of pheochromocytoma.
出处
《中国中西医结合外科杂志》
CAS
2011年第6期580-582,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
