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CD98在肺癌中的研究进展

CD98 in lung cancer
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摘要 CD98为细胞表面跨膜蛋白二聚体，通过激活相关蛋白来调控细胞内的信号传导，进而影响细胞的极性、增殖、黏连、迁移等特性，在肿瘤发生发展方面发挥重要作用。目前的研究表明CD98可能成为一种在肺癌诊断、治疗及判断预后方面非常有前景的的标志物。 CD98 is a transmembrane heterodimer of cell surface. It regulates cell signaling pathway by activating some correlated proteins, and controls cell polarization, proliferation, adhesion and migration. CD98 plays an important role in the development of cancer and may he a novel tumor marker for diagnosis and prognosis in lung cancer.
作者 刘阳 岳文涛 许绍发
机构地区 首都医科大学附属北京胸科医院胸外二科 北京市结核病胸部肿瘤研究所细胞室
出处 《国际肿瘤学杂志》 CAS 2011年第12期927-929,共3页 Journal of International Oncology
关键词 抗原 CD98 肿瘤标记 生物学 肺肿瘤 预后 Antigens, CD98 Tumor markers, biological Lung neoplasms Prognosis
分类号 R734.2 [医药卫生—肿瘤]
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参考文献16

  • 1Cantor J, Slepak M, Ege N, et al. Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity. J Immunol, 187(2) :851-860.
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国际肿瘤学杂志
2011年 第12期

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