摘要
研究发现微小RNA（miRNA）参与细胞的增殖、分化和凋亡等细胞进程，在包括食管癌在内的各种肿瘤中异常表达。miRNA与癌基因或者抑癌基因的mRNA完全或者部分配对，促进mRNA的降解或者抑制mRNA的翻译。研究发现很多miRNA在食管癌的发生发展和预后中发挥重要作用。miR-21与细胞程序性死亡蛋白4（PDCD4）mRNA相结合，抑制PDCD4的翻译从而促进食管癌的发生。miR-106b-25多顺反子经基因扩增激活，其表达产物抑制P21和Bim蛋白的表达，促进了食管癌的发生和发展。
Researches find that microRNAs （miRNAs） participate in cell proliferation, differentiation and apoptosis. Dysrcgulation of miRNA exist in almost all kinds of tumors, including esophageal cancer. MiRNAs bind to mRNA of oncogene or tumor suppressor gene by perfectly or partly base-pair complementarity, and then, promote mRNA degradation or inhibit translation of target mRNA. Recently studies have comfirmed that miRNA functions as a significant regulator in esophageal cancer and it is involved in tumorigenesis, develop- ment and prognosis. MiR-21 binds to programmed cell death 4（PDCIM） mRNA and inhibits the translation of PDCIM, then promotes tumorigenesis of esophageal cancer. MiR-106-25 polycistron is activated by genomic amplification, and then suppresses the expressions of P21 and Bim, and subsequently promotes the occurrence and progress of esophageal cancer.
出处
《国际肿瘤学杂志》
CAS
2011年第12期920-922,共3页
Journal of International Oncology
基金
基金项目：浙江省自然科学基金资助项目（Y2080749,5（2091110）
卫生部-浙江省重大科研基金资助项目（WKJ2010-2-004）
浙江省重大科技专项计划项目（2011C13039-1）
关键词
微RNAS
食管肿瘤
MicroRNAs
Esophageal neoplasms
