摘要
目的探究血浆(1,3)-β-D葡聚糖对侵袭性(深部)真菌感染(invasive fungal infection,IFI)诊断价值。方法用两种不同方法检测67例疑似IFI患者的标本,了解其真菌感染情况;分析比较健康和确诊IFI两组血浆(1,3)-β-D葡聚糖的水平。结果 G试验动态浊度法和传统真菌培养阳性率分别为47.8%和22.4%,两者差异有统计学意义(χ2=9.47,P<0.01);IFI组血浆(1,3)-β-D葡聚糖水平(475.3±375.6)pg/ml明显高于健康人群组(6.2±5.6)pg/ml(t=8.94,P<0.01);血浆(1,3)-β-D葡聚糖使用临界值为20.0 pg/ml,诊断真菌感染的阳性预测值、阴性预测值和准确率分别为83.0%、100.0%和91.1%。结论血浆(1,3)-β-D葡聚糖是反映IFI的一个良好指标,可用于IFI的早期诊断,又可为IFI患者的疗效评价指标。
Objective To study diagnostic value of plasma（1,3）-β-Dglucan in invasive fungal infection. Methods Tow different methods were used to determine specimens of 67 suspected cases patients with IFI,Learned about fungal infection status;To analysis and compare the levels of plasma（1,3）-β-d-glucan in the groups of health and confirmed IFI.Results The positive rate of G-test and fungal culture was 47.8% and 22.4%,Showed significant different（χ2=9.47,P0.01）.Patients with IFI showed a higher level（475.3±375.6 pg/ml） of plasma（1,3）-β-D-glucan than that（6.2±5.6 pg/ml） of health group（t=8.942,P0.01）.The critical value of plasma（1, 3）-β-D-glucan were used as 20.0 pg/ml.The positive predictive value,negative predictive value and precision rate for G-test were 83.0%,100.0% and 91.1%. Conclusions The level of plasma（1,3）-β-D-glucan can be used as a index for early diagnosis of IFI,and as a index for curative effect,and it is of great value to working out the IFI.
出处
《实用预防医学》
CAS
2011年第12期2392-2394,共3页
Practical Preventive Medicine
