摘要
目的探讨白芍总苷(TGP)治疗干燥综合征(SS)的临床疗效。方法选择2008年3月～2011年4月就诊的60例干燥综合征患者,随机平分为两组;对照组:给予甲氨蝶呤10mg/周,口服。治疗组在对照组的基础上加服白芍总苷(0.3g/粒),0.6g/次,顿服。疗程均为6个月。观察对比治疗前后患者的临床症状改善情况和类风湿因子(RF)、血沉(ESR)、C反应蛋白(CRP)、唾液流率(方糖法)、Schirmer试验、血清γ-球蛋白(采用琼脂糖凝胶电泳法)等指标的改善情况,并密切观察不良反应的发生情况。结果经过6个月的治疗后,两组患者在RF、ESR、CRP、唾液流率(方糖法)、Schirmer试验、血清γ-球蛋白等方面对照与治疗前均有明显改善,统计学意义明显,P<0.05。治疗组和对照的的总有效率分别为83.3%和56.7%,具有统计意义,P<0.05。结论 TGP联合甲氨蝶呤治疗SS疗效性好,安全性高。
Objective To investigate the clinical efficacytotal glueosides of paeony（TGP） treatment of Sjogren＇s syndrome（SS）.Methods 60 cases of patients with Sjogren＇s syndrome were selected from March 2008 to April 2011,randomly divided into two groups;Control group：given methotrexate 10 mg a week,orally;Treatment group were based on the additional services TGP（0.3g /grain）,0.6g /second,three times a day.All was treatment for 6 months.Observed And compared before and after treatment of patients with improvement of clinical symptoms and rheumatoid factor（RF）,erythrocyte sedimentation rate（ESR）,C-reactive protein（CRP）,salivary flow rate（sugar method）,Schirmer test,serum γ-globulin（agar sugar gel electrophoresis） and other indicators of improvement,and closely observe the occurrence of adverse reactions.Results After 6 months of treatment,two groups of patients in the RF,ESR,CRP,salivary flow rate（sugar method）,Schirmer test,serum γ-globulin and other aspects of the control and treatment showed significant improvement,statistically significant significant,P0.05.Treatment group and the control of the total efficiency of 83.3% and 56.7%,with statistical significance,P0.05.Conclusion SS TGP methotrexate treatment efficacy is good,safe.
出处
《当代医学》
2011年第36期10-11,共2页
Contemporary Medicine
