摘要
目的了解南京医科大学附属苏州市立医院临床分离的鲍曼不动杆菌属对15种抗菌药物的耐药性,为临床抗菌药物的选择和控制感染提供依据。方法收集南京医科大学附属苏州市立医院2009年10月至2010年11月所有临床分离的鲍曼不动杆菌,鉴定采用法国生物梅里埃公司ATB细菌鉴定仪,根据美国临床实验室标准化协会推荐的纸片扩散法做体外药敏试验。结果 195株鲍曼不动杆菌对米诺环素最为敏感,敏感率为80.5%,其次是美罗培南、亚胺培南和头孢哌酮/舒巴坦的敏感率分别为65.1%、63.6%和56.9%,对哌拉西林、庆大霉素、复方新诺明、环丙沙星、左氧氟沙星的耐药率分别为61.5%、59.0%、57.4%、51.8%和50.3%。结论鲍曼不动杆菌是医院感染的重要病原菌,耐药率高,部分菌株呈多重耐药,应根据药敏试验结果合理选用抗菌药物。
Objective To investigate the drug resistance diversity of Acinetobacter baumannii to 15 antibacterial,and to provide evidence for clinical application of antibacterial and infection controlling by analyzing the susceptibility test results. Methods Clinically isolated Acinetobacter baumannii were collected from October 2009 to November 2010 in our hospital. Bacterial identification was carried out with ATB device. Antimicrobial susceptibility testing in vitro was carried out by disk diffusion method according to CLSI judgement standard. Results The drug sensitivity test results of the 195 strains of Acinetobacter baumannii showed that minocycline sensitivity rate was 80.5%, which was the highest, followed by meropenem, imipenem and cefoperazone-sulbactam with the sensitivity 65.1%, 63.6%and 56.9% ,respectively. The resistance rate of A. baumannii to piperacillin, gentamicin, trimethoprim-sulfamethoxazole, ciprofloxacin, levofloxacin were 61.5%, 5 9.0 %, 5 7.4%, 5 l. 8%, 5 0. 3%, respectively. Conclusion Acinetobacter baumannii is one of the most important pathogen in nosocomial infections. Some strains are highly resistant and a small number of bacteria are multidrug resistant to Acinetobacter baumannii. Treatment should be guided by the drug sensitivity test results.
出处
《检验医学与临床》
CAS
2011年第24期2973-2974,共2页
Laboratory Medicine and Clinic
关键词
鲍曼不动杆菌
耐药性
抗菌药物
acinetobacter baumannii
drug resistance
antibacterial drug
