摘要
目的研究青年肝静脉型布加综合征(BCS)患者血浆维生素B12、叶酸与同型半胱氨酸(Hcy)的相关性。方法青年肝静脉型BCS患者60例,同期健康对照组60例,均留取空腹肘静脉血,BCS患者介入治疗时另取肝静脉血,免疫荧光反应测定血浆Hcy浓度,放射免疫法测定血清维生素B12及叶酸浓度。结果 BCS组肝静脉及肘静脉血Hcy[分别为(21.40±9.82)和(20.38±8.40)mmol/L]浓度均高于健康对照组[(16.64±5.16)mmol/L],两组间差异有统计学意义(P<0.05)。BCS组血清叶酸及维生素B12浓度分别为(4.10±1.85)mg/L和(432.48±104.36)ng/L,健康对照组分别为(6.40±1.91)mg/L和(447.60±115.48)ng/L,两组差异无统计学意义。结论青年肝静脉型BCS患者体内存在高Hcy浓度状态,高Hcy浓度状态与体内叶酸、维生素B12浓度无明显相关性。
Objective To study the relativity of the plasma homocysteine（Hcy）,serum folic acid and Vit B12 levels in young patients of Budd-Chiari syndrome（BCS） with hepatic vein obstructive. Methods 60 young patients of BCS with hepatic vein obstructive and 60 healthy people with the same conditions were collected and taking the fasting vein blood, and the BCS patients were taking hepatic venous blood. The serum folic acid, Vit B12 were tested by radioimmunoassay ,and plasma Hey was measured hy immunofluorescence. Results The mean plasma Hcy level in BCS and controls were （21.40±9.82） mmol/L and （20.38 ±8.40） mmol/L respectively, with significant difference （P〈0.05）. But the mean serum folic acid and Vit B12 levels in BCS group and controls were （4. 10±1.85）mg/L vs （6.40±1.91）mg/L and （432.48±104.36） ng/L vs （447.60±115.48） ng/L respectively. There was no statistical significance. Conclusion There is high plasma Hey level in patients with BCS with hepatic vein obstruction. The high plasma Hcy levels in BCS patients has no significant correlation with the folic acid and Vit B12 levels.
出处
《检验医学与临床》
CAS
2011年第24期2949-2950,2953,共3页
Laboratory Medicine and Clinic
基金
国家十一五科技计划支撑课题(2006038073024)
