摘要
急性脑梗死(ACI)是中老年人群中的常见病,具有高发病率、高致残率和高死亡率的特点,是危害我国人民群众生命健康的主要原因之一,其发病机制十分复杂。近年来对于血小板活化功能亢进与缺血性脑血管病的关系日益受到重视。
Objective To observe and compare the effects of aspirin and clopidogrel on CD62P and CD63 expression in platelets of patients with acute cerebral infarction （ACI）. Methods 72 patients with ACI were divided into two groups： aspirin group and clopidogrel group. Before and after treating, the expression of CD62P and CD63 in patients with ACI were detected by flow cytometry. The effects of the aspirin and the clopidogrel were observed and compared. Results After treating, the expression of CD62P and CD63 in the two groups were lower than that before treating. The levels of CD62P and CD63 in the clopidogrel group were obviously lower than those in the aspirin group, the differences were significant. Conclusions For the patients with ACI, clopidogrel can more deeply repress the expressions of CD62P and CD63 in platelets than aspirin. And treatment with clopidogrel is probable more efficient.
出处
《心脑血管病防治》
2011年第6期433-435,共3页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
基金
湖州市科技计划项目(2009YSB08)
