摘要
目的建立万古霉素谷浓度为10～20μg·mL-1的给药设计方案。方法 采用Matxke方法估算药物动力学参数,以目标谷浓度为10～20μg·mL-1,利用药物动力学参数设计给药方案,比较预测谷浓度与实际谷浓度的差别并计算AUC0～24/MIC。结果43例患者的预测谷浓度为(15.25±1.60)μg·mL-1,实际谷浓度为(14.47±2.46)μg·mL-1,预测谷浓度的ME为0.78μg·mL-1(95%CI:0.13～1.42),MAE为1.57μg·mL-1(95%CI:1.09～2.06),RMAE为2.21μg·mL-1(95%CI:1.41～2.79)。预测谷浓度与实际谷浓度具有相关性(P<0.001,r=0.535);43例患者中有41例(95.35%)患者的实际谷浓度在10～20μg·mL-1。患者实际日剂量明显高于说明书推荐剂量(P<0.001)。当MIC≤1μg·mL-1时,43例患者中有42例(97.67%)患者的AUC0～24/MIC均可>400。结论本研究建立的给药方案可以满足谷浓度为10～20μg·mL-1的要求。
Objective To establish vancomycin dosage design regimens based on trough concentrations of 10-20 μg · mL^-1. Methods Pharmacokinetic parameters were estimated by Matzke method. Vancomycin dosage regimens were designed according to pharmacokinetic parameters and target trough concentrations ranging 10-20μg · mL^-1. We compared the predicted trough concentrations with measured trough concentrations and calculated AUCo-24/MIC. Resuits Predicted trough concentrations and measured trough concentrations were （15.25 ± 1.60） μg · mL^-1 and （14.47±2.46）μg · mL^-1 respectively. ME, MAE and RMAE were 0.78 μg · mL^-1 （95%CI： 0.13-1. 42） , 1.57 μg · mL^-1 （95%CI： 1.09-2.06） and 2.21 μg · mL^-1（950/00CI： 1.41-2.79） respectively. There was correlation between predicted trough concentrations and measured trough concentrations （P〈0. 001, r = 0. 535）. The trough concentration of 41 out of the 43 patients （95.35%） ranged 10-20μg · mL^-1. Actual daily doses were significantly higher than those recommended by manufacturer＇s instruction. In all the 43 patients, AUC0-24/MIC in 42 patients （97.67%） was above 400 when MIC≤1μg · mL^-1. Conclusion The established dosage regimens meet the requirement of trough concentration ranging 10-20μg · mL^-1.
出处
《中南药学》
CAS
2011年第11期811-814,共4页
Central South Pharmacy
关键词
万古霉素
高谷浓度
给药方案
vancomycin
high trough concerntratiom dosage regimen
