摘要
目的分析我国区县级结核病防治机构(简称"结防机构")就诊患者痰涂片和培养结果之间的关系。方法选取全国耐药性基线调查期间通过分层整群抽样方法随机抽取的18个区县级结防机构,自2007年4—12月连续纳入的1230例初治和复治涂阳患者痰标本,共计3550份,采取"三涂两培"的方法(即3份痰标本均为阳性,选取阳性级别高的2份痰标本进行培养;3份痰标本2份阳性,选取2份阳性痰标本进行培养;3份痰标本1份阳性,选取阳性标本和1份质量好的阴性标本进行培养),完成涂片和培养试验,计算患者即时痰、夜间痰和晨痰不同痰标本的涂片阳性率和培养阳性率,分析涂片和培养结果的相关关系。结果结核病患者即时痰、夜间痰和晨痰涂片阳性率分别为78.8%(917/1164)、87.0%(1070/1230)和90.0%(1040/1156),即时痰、夜间痰和晨痰培养阳性率分别为96.9%(504/520)、97.1%(881/907)和97.8%(709/725),对2147份痰标本涂片结果阳性级别和培养结果阳性级别进行趋势χ2检验,发现两者存在一定的线性趋势相关关系(χ2=206.2,P<0.01)。结论涂片结果在一定程度上可为培养结果提供依据,涂片阳性级别越高,培养阳性级别也越高。
Objective To analyze the smear and culture results of patients from county TB dispensaries.Methods A total of 3550 smear positive specimens from 1230 new and retreatment patients recruited in eighteen county TB control institutions according to stratified cluster sampling method from April to December 2007,three specimens for smear and two specimens for culture experiment.The positive rates of smear and culture result among the spot,evening and morning specimens were analyzed and the correlation of smear and culture results were observed.Results The positive rates of smear result for morning,spot and evening specimen were 78.8%（917/1164）,87.0%（1070/1230） and 90.0%（1040/1156）.The positive rates of culture result for morning,spot and evening specimen were 96.9%（504/520）,97.1%（881/907） and 97.8%（709/725）.The level of smear and culture result in 2147 specimens were analyzed by trend χ2 test,we found there was linear trend of correlation between smear and culture results（χ2=206.2,P0.01）.Conclusion Smear results can provide some hint for culture results in some extent.If the smear positive level is high,the culture positive level will also high.
出处
《中国防痨杂志》
CAS
2011年第12期798-802,共5页
Chinese Journal of Antituberculosis
基金
"十一五"国家科技重大专项(2008ZX10003-009)
关键词
分枝杆菌
结核
细菌学技术
多中心研究
Mycobacterium tuberculosis
Bacteriological techniques
Multicenter study
