摘要
目的探讨北京市亚北地区妇科门诊就诊的高危人群人乳头瘤病毒（HPV）的感染情况。方法采用导游杂交基因芯片技术（HybriMax）对2010年10月至2011年9月在航空总医院妇科门诊就诊1069例患者的宫颈脱落上皮细胞样本进行HPV感染筛查，对HPV阳性结果进行分析。结果在1069例患者中，共检出HPV阳性311例，检出率为29．09％；检出20个亚型，其中阳性率最高的型别为HPV-16，其余依次为：HPV-52、58、53。311例阳性患者中，检出高危型感染285例，占91．64％（285／311），低危型26例，占8．36％；单一型感染286例，占91．96％（286／311），混合型感染25例，占8．04％。HPV感染的高峰年龄在20。24岁，阳性检出率达43．15％，各年龄组间HPV感染的检出率差异有统计学意义（χ2=28．05，P〈0．01），45岁及以上人群感染高危型的比例较高（97．30％，72／74），与45岁以下感染率（87．87％，213／237）相比差异有统计学意义（χ2=21．00，P〈0．05）。结论北京市亚北地区妇科门诊就诊的高危人群HPV感染率较高，且以感染高危型HPV为主。
Objective To discuss the human papiUomavirus （HPV） infection in outpatient women in Yabei region of Beijing. Methods A cluster sampling prevalence analyses were performed during Oct 2010 to Sep 2011 among 1069 women attending gynecological outpatient clinic. Epithelial cell samples were obtained for subtype screening by HybriMax, and positive results were statistical analyzed. Results 311 cases was positive and the positive rate was 29.09% （311/1069）. 20 subtypes were detected totally, of which HPV-16 was the most common type, followed by HPV-52, HPV-58 and HPV-53. The high-risk HPV subtype infection accounted for 91.64% （285/311）, low-risk 8.36% （26/ 311） ; single HPV infection accounted for 91.96% （286/311）, multiplex infection 8.04% （25/311）. The peak age of them was 20-24 years old, and the positive rate was 43.15%. There were significant differences about the HPV-positive rate among each age groups（ χ2 = 28.05, P 〈 0.01）. The high-risk subtype infection rate was higher in 45 year and older （97.30% ,72/74） than those in below 45 years old （87.87% ,213/237） （ χ2 = 21.00, P 〈 0.05）. Conclusions The rate of HPV infection in Yabei region of Beijing is high, and the subtype is characterized by high-risk HPV.
出处
《国际流行病学传染病学杂志》
CAS
2011年第6期392-395,共4页
International Journal of Epidemiology and Infectious Disease
