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肿瘤坏死因子基因6个SNPs与河南汉族原发性高血压的相关性研究 被引量：3

Correlation between TNF α and β Gene Polymorphisms and Essential Hypertension in HAN Chinese of Henan Province
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摘要 目的探讨肿瘤坏死因子基因6个SNPs位点多态性与河南汉族原发性高血压(EH)的相关性。方法采用限制性扩增片段长度多态性(PCR-RFLP)的方法检测TNF-α启动区基因-238G>A、-308G>A、-850C>T、-857C>T、-863C>A及TNF-β第一内含子基因+252G>A多态性,并运用卡方检验探讨各SNP位点多态性与EH的相关性。结果 TNF-α-308G>A位点基因型分布和等位基因频率在人群中存在差异显著性(χ2=6.407,P=0.041;χ2=4.781,P=0.029),EH组中,TNF-α-308G>A中基因型GA+AA人群的收缩压(SBP)、舒张压(DBP)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、尿酸(UA)及空腹血糖(FPG)含量明显高于GG基因型人群(P<0.05);TNF-α基因-238G>A、-850C>T、-857C>T、-863C>A及TNF-β基因+252G>A多态性各基因型及等位基因频率在EH组和对照组的分布差异无统计学意义。结论 TNF-α基因-308G>A位点基因多态性与河南汉族原发性高血压的发病相关。TNF-α-238G>A、-850C>T、-857C>T、-863C>A及TNF-β+252G>A位点基因多态性与河南汉族原发性高血压无关联。 Objective To investigate the correlation between 6 SNPs on tumor necrosis factor gene and essential hypertension （EH） in Han Chinese in Henan province. Methods Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was used to evaluate the gene polymorphisms including TNF-α-238G〉A, -308G〉A, -850C〉T, -857C 〉T, -863C 〉A gene and TNF-β ＋252G〉A gene in 260 unrelated EH patients （EH group） and 394 healthy population （control group）. Results The frequencies of the GA ＋AA genotype and allele of TNF-α-308G 〉A in EH patients were significantly higher than those in heahh control group （x2=6.407andx2=4.781,allP〈0.05）,inEHpatients, theSBP, DBP, HDL, LDL, UA and FGB values were significant difference between the GA＋AA genotype and GG genotype subgroups （P〈0.05）. There was no significant difference in genotype and allelic frequency of the TNF-α-238G〉A, -850C〉T, -857C〉T, -863C〉A gene and TNF-β ＋252G 〉A polymorphism between healthy subjects and EH patients. Conclusion The TNF-α-308G 〉A gene polymorphism is positively eorrelated with EH of Han Chinese in Henan. And the TNF-α-238G〉A, -850C〉T, -857C〉T, -863C〉A gene and TNF-β＋252G〉A gene polymorphism is not associated with the susceptibility to EH.
作者 郭利伟 李端 黄艳梅 冯志博 康利霞
机构地区 新乡医学院基础医学院 新乡医学院生命科学技术系 新乡医学院第三附属医院检验科
出处 《中国慢性病预防与控制》 CAS 北大核心 2011年第6期571-573,共3页 Chinese Journal of Prevention and Control of Chronic Diseases
基金 河南省教育厅自然科学基金(2008A310010)
关键词 肿瘤坏死因子 原发性高血压 单核苷酸多态性 河南汉族 Tumor neerosis factor Essential hypertension Single nucleotide polymorphism Han nationality in Henan
分类号 R544.1 [医药卫生—心血管疾病]
  • 相关文献

参考文献8

  • 1Carmine S, Ernesto EL. Inflammation in hypertension [J]. Curr Opin Nephrol Hypertens,2006, 15: 152-158.
  • 2Brown RD, Ambler SK, Mitchell MD, et al. The cardiac fibroblast: Therapeutic target in myocardial remodeling and failure [J]. Annu Rev Pharmacol Toxicol, 2005, 45: 657-687.
  • 3Bogdanski P, Pupek-Musialik D, Dytfeld J, et al. Plasma homocysteine is a deter minant of tissue necrosis factor-alpha in hypertensive patients [J]. Biomed Pharmacother, 2008, 62: 360-365.
  • 4Bautista LE, Vera LM, Arenas IA, et al. Independent association between inflammatory markers (Creactive protein, interleukin-6, and TNF-alpha) and essential hypertension[J]. J Hum Hypertens, 2005, 19: 149 -154.
  • 5吴旭斌,周胜华.肿瘤坏死因子α基因G-308A多态性与高血压相关性[J].高血压杂志,2004,12(5):415-418. 被引量：6
  • 6Kim KI, Lee JH, Chang HJ, et al. Association between blood pressure variabihty and inflammatory marker in hypertensive patients[J]. Circ J, 2008, 72: 293-298.
  • 7Azmy IA, Balasubramanian SP, Wilson AG, et al. Role of tumor necrosis factor gene polymorphisms (-308 and -238) in breast cancer susceptibility and severity [J]. Breast Cancer Res, 2004,6: 395-400.
  • 8Krikovszky D, Vasarhelyi B, TothHeyn P, et al. Association between G-308A polymorphism of the tumor necrosis factor-alpha gene and 24-hour ambulatory blood pressure values in type 1 diabetic adolescents [J]. Clin Genet, 2002, 62:474-477.

二级参考文献13

  • 1Libby P. Vascular cells produce and respond to cytokines.In: Hansson GK, Libby P, eds. Immune function of the vessel wall[M]//The Netherlands: Harwood Academic Publishers,1996,56-64.
  • 2Kahaleh MB, Fan PS. Effect of cytokines on the production of endothelin by endothelial cells[J].Clin Exp Rheumatol,1997,15:163-167.
  • 3Wilson AG, Symons JA, McDowell TL, et al. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation[J].Proc Natl Acad Sci USA,1997,94:3195-3199.
  • 4Kroeger KM, Carville KS, Abraham LJ.The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription[J].Mol Immunol,1997,34:391-9.
  • 5Bouma G, Crusius JB, Oudkerk Pool M, et al.Secretion of tumour necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles: relevance for inflammatory bowel disease[J].Scand J Immunol,1996,43:456-463.
  • 6Krikovszky D, Vasarhelyi B, Toth-Heyn P, et al. Association between G-308A polymorphism of the tumor necrosis factor-alpha gene and 24-hour ambulatory blood pressure values in type 1 diabetic adolescents[J].Clin Genet,2002 ,62:474-477.
  • 7Pausova Z, Deslauriers B, Gaudet D, et al. Role of tumor necrosis factor-α gene locus in obesity, and obesity-associated hypertension in French Caucasians[J].Hypertension,2000,36:14-19.
  • 8Keatings VM, Cave SJ, Henry MJ, et al. A polymorphism in the tumor necrosis factor-gene promoter region may predispose to a poor prognosis in COPD[J].Chest,2000,118:971-975.
  • 9D rffel Y, Latsch C, Stuhlm ller B, et al. Preactivated peripheral blood monocytes in patients with essential hypertension[J].Hypertension,1999,34:113-117.
  • 10Ito H, Ohshima A, Tsuzuki M, et al. Association of serum tumour necrosis factor-alpha with serum low-density lipoprotein-cholesterol and blood pressure in apparently healthy Japanese women[J].Clin Exp Pharmacol Physiol,2001,28:188-192.

共引文献5

同被引文献54

  • 1郭利伟,杨彩玲,黄艳梅,李端,祁英杰,韩金红,杨保胜.肿瘤坏死因子α基因-238G>A及-857C>T多态性与河南汉族群体原发性高血压[J].河南师范大学学报（自然科学版）,2011,39(3):126-130. 被引量：2
  • 2吴旭斌,周胜华.肿瘤坏死因子α基因G-308A多态性与高血压相关性[J].高血压杂志,2004,12(5):415-418. 被引量：6
  • 3龚艳春,李华,沈韵,郭冀珍,朱鼎良.肥胖高血压病患者肿瘤坏死因子基因多态性[J].高血压杂志,2005,13(1):19-23. 被引量：2
  • 4Savoia C,Sada L,Zezza L,et al.Vascular inflammation and endothelial dysfunction in experimental hypertension[J].Int J Hypertens,2011:281240.
  • 5Badano I,Schurr TG,Stietz SM,et al.TNF promoter SNP variation in Amerindians and white-admixed women from Misiones,Argentina[J].Int J Immunogenet,2013,40(3):216-221.
  • 6Bogdanski P,Pupek-Musialik D,Dytfeld J,et al.Plasma homocysteine is a determinant of tissue necrosis factor-alpha in hypertensive patients[J].Biomed Pharmacother,2008,62(6):360-365.
  • 7Bautista LE,Vera LM,Arenas IA,et al.Independent association between inflammatory markers(C-reactive protein,interleukin-6,and TNF-alpha)and essential hypertension[J].J Hum Hypertens,2005,19(2):149-154.
  • 8Bogdanski P,Pupek-Musialik D,Dytfeld J,et al.Plasma homocysteine is a determinant of tissue necrosis factor-alpha in hypertensive patients[J].Biomed Pharmacother.2008,62(6):360-365.
  • 9Sun M,Chen M,Dawood F,et al.Tumor necrosis factoralpha mediates cardiac remodeling and ventriculardysfunction after pressure overload state[J].Circulation,2007,115(11):1398-1407.
  • 10Kim KI,Lee JH,Chang HJ,et al,Association between blood pressure variability and inflammatory marker in hypertensive patients[J].Circ J,2008,72(2):293-298.

引证文献3

二级引证文献6

中国慢性病预防与控制
2011年 第6期

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