摘要
目的:观察风湿性心脏病(风心病)二尖瓣狭窄肺动脉高压患者肺病理改变特点,为临床处理提供理论依据。方法:选择37例风心病二尖瓣狭窄合并肺动脉高压的手术换瓣患者,在手术时取右肺中叶组织,对其病理改变进行定性和定量研究。以6例主动脉瓣病变、肺动脉压正常、行主动脉瓣置换术的患者为对照。结果:风心病二尖瓣狭窄合并肺动脉高压患者的肺组织结构存在着不同程度的改变。严重肺动脉高压组的肺肌型动脉中层厚度指数(MT/R)明显高于肺动脉高压组和对照组,肺动脉高压组的MT/R也明显高于对照组。根据MT/R的病理分级,81%的患者在轻至中度。结论:肺血管病变的严重程度和术前肺动脉压力有关,但大部分患者的肺血管病理改变仅为轻到中度。
Objective: To review the pathological characteristics of the lungs in mitral stenosis with pulmonary hypertension, and provide evidence for clinical treatment. Methods: Pulmonary pathological changes in 37 patients with rheumatic mitral stenosis and secondary pulmonary hypertension received mitral valve replacement. Six patients of aortic valve disease without pulmonary hypertension received aortic valve replacement and were taken as control. The lung biopsies were obtained from the middle lobe of the right lung in operation. Pulmonary muscular arteries were studied quantitatively and qualitatively. Results: All patients with mitral stenosis showed various degrees of vascular and other associated parenchymal changes. The structural changes in the muscular arteries was graded according to the degree of MT/R. There was 81% of patients with mitral stenosis in mild to moderate degree. Conclusion: The pulmonary vascular pathological changes of patients who have rheumatic mitral stenosis with pulmonary hypertension are related to the level of preoperative pulmonary artery pressure. And in most of them the pulmonary vascular pathological changes are in mild to moderate degree.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1999年第12期997-999,F003,共4页
Academic Journal of Second Military Medical University
基金
全军"九五"医药卫生科研基金!项目编号 96 Z0 3 1
