摘要
目的 研究糖蛋白ＣＤ４４（ 细胞膜粘附分子） 在乳腺癌中的表达及其表达程度与预后的关系。 方法 采用免疫组织化学方法，对１４０ 例有随访结果的乳腺癌和３７ 例乳腺良性病变的石蜡切片作ＣＤ４４ 染色并进行分析。 结果 ＣＤ４４ 在良、恶性乳腺病中的表达有显著差异（ Ｐ＜ ０－００１）。ＣＤ４４ 在乳腺癌中的表达随着组织学级别的升高而升高。ＣＤ４４ 在肿瘤中的过度表达与预后差相关。当ＣＤ４４ 与ＭＴ（ 金属硫蛋白） 在肿瘤中双表达其五年生存率明显降低。ＣＤ４４ 在肿瘤中的表达与手术时腋下淋巴结有无转移无相关性，但在腋下有淋巴结转移的肿瘤伴ＣＤ４４阳性表达的死亡率高于ＣＤ４４ 阴性表达。 结论 ＣＤ４４
PURPOSE To study the expression of CD44 in breast diseases and the association of CD44 expression to prognosis.METHODS 140 female breast cancer specimens and 37 benign specimens(formalin fixed paraffin embedded sections)were studied with anti CD44 monoclonal antibody.RESULTS There was a statistically significant association between expression of CD44 in breast benign and malignant diseases. The expression of CD44 increase with rise in histological grade grade. The over expression of CD44 is closely related to poor prognosis and five year survival.The prognosis was poorer,when these was expression of both MT and CD44 in breast cancer. There was no association between CD44 expression and lymph node metastasis.But the mortality in the cases with lymph node metastasis having positive CD44 expression was higher than in those cases with negative CD44 expression.CONCLUSIONS CD44 test may be useful as a marker to assess the prognosis in breast carcinoma.
出处
《中国癌症杂志》
CAS
CSCD
1999年第4期281-283,I004,共4页
China Oncology
