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脑源性神经营养因子与抑郁症的研究进展 被引量：12

Advances in Relationship Between Brain-derived Neurotrophic Factor and Depressive Disorder
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摘要 脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)是人体内含量最多的神经营养因子,在神经系统的发育和功能维持中起至关重要的作用.研究表明,抗抑郁剂通过提高BDNF表达来促进神经细胞的生存,增加突触可塑性及神经发生. Brain-derived neurotrophic factor（BDNF） is the most widely distributed neurotrophin in the central nervous system（CNS）,serving many biological functions such as neural survival,differentiation,and plasticity. Treating the antidepressant drug could promote nerve cell survival and increase the synaptic plasticity and neurogenesis by improving BDNF expression.
作者 周小江 胡园 刘屏
机构地区 中国人民解放军总医院临床药理研究室
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2011年第12期1085-1090,共6页 Progress In Biochemistry and Biophysics
基金 国家自然基金资助项目(30973891)~~
关键词 抑郁症 脑源性神经营养因子(BDNF) 海马 酪氨酸激酶受体B(TrkB) depression BDNF hippocampus TrkB
分类号 Q421 [生物学—神经生物学]
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  • 3Kim Y K, Lee H P, Won S D, et al. Low plasma BDNF is associated with suicidal behavior in major depression. Prog Neuropsychopharmacol Biol Psychiatry, 2007, 31(1): 78-85.
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生物化学与生物物理进展
2011年 第12期

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