摘要
背景:肺组织结构复杂,病变周期长,具有主动归巢与调控功能的干细胞植入的治疗手段具有巨大的应用前景。目的:全面了解成体干细胞治疗肺疾病与损伤的研究进展。方法:由第一作者检索Pubmed数据库中2011年前发表的有关成体干细胞与肺损伤,多系分化及组织重建等方面的文章,排除重复性研究。结果与结论:共检索到135篇相关文献,保留其中50篇进行综述。研究表明以骨髓来源的间充质干细胞为代表的成体干细胞具有较强的多系分化潜能,可用于治疗肺部疾病,可参与损伤修复甚至组织再生。其治疗机制及相关影响因素还有待进一步研究。
BACKGROUND：Stem cells with active homing function and regulation has a great application prospect to lung regeneration due to the lung tissue with complex structure and long disease cycle.OBJECTIVE：To overally understand the progress of adult stem cells in treatment of lung diseases and injury.METHODS：The first author retrieved PuMed for articles about adult stem cells for lung injury published before 2011.Repetitive articles were excluded.RESULTS AND CONCLUSION：Totally 135 articles were retrieved,and finally 50 articles were included in result analysis.Bone marrow-derived mesenchymal stem cells as the representative of adult stem cells have a strong multi-differentiation potential for the treatment of lung disease,which can involved in wound healing and tissue regeneration.However,the therapeutical mechanism and related influential factors need further studies.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第45期8520-8524,共5页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
国家自然科学基金(81100366)~~
