摘要
目的研究食管癌患者^18F-FDG PET／CTMTV与预后的关系。方法回顾性分析2004年3月至2008年3月行^18F—FDG PET／CT检查的49例Ⅰ—Ⅳa期的食管癌患者，均经病理检查证实，随访资料完整。患者均行食管癌切除术，随访截止至2009年11月，中位随访时间为29（8～57）个月。应用Kaplan—Meier法及Cox比例风险模型分析年龄、性别、肿瘤位置、肿瘤组织分化程度、PET／CT示肿瘤长径、美国肿瘤联合会（AJCC）分期、转移淋巴结个数、原发灶SUVmax及MTV与预后的关系。结果在单因素分析中，仅AJCC分期[χ^2=16．206，危险比（HR）=1．177，P〈0．001），淋巴结分期（N）（χ^2=9．536，HR=10．833，P=0．002），浸润深度（T）（χ^2=5．810，FIR=2．397，P=0．016），淋巴结转移个数（χ^2=11．423，HR=1．567，P=0．001）、MTV（χ^2=3．872，HR=2．433，P=0．049）对预后存在预测作用。对以上变量行多因素分析，仅AJCC分期及MTV是独立的预后因子（r=4．525，HR=1．170，P=0．033；χ^2=4．875，HR=3．071，P=0．027）。Kaplan-Meier生存分析显示术前低MTV组比高MTV组的生存率高（Log—rank检验，χ^2=4．186，P=0．041）。结论MTV与食管癌术后患者的预后密切相关。对于高MTV患者，术后可能需要接受更加积极的治疗。
Objective To evaluate the prognostic value of MTV on is F-FDG PET/CT in patients with esophageal cancer. Methods Forty-nine patients with esophageal cancer underwent lSF-FDG PET/CT scan before surgery. The median follow-up time for the patients was 29 months （range, 8- 57 months ）. The prognostic significance of MTV, age, sex, histologic grade, SUVm~ of the primary tumor, tumor size measured on PET/CT, T stage, N stage, M stage, American Joint Committee on Cancer （AJCC） stage, number and location of lymph nodes metastases were assessed by Kaplan-Meier analysis and multivariate Cox model. Results In the univariate analysis, AJCC stage （χ^2 = 16. 206, hazard ratio （HR） = 1. 177, P 〈 0. 001）, N stage （χ^2 = 9. 536, HR = 10. 833, P = 0. 002）, T stage （χ^2 = 5. 810, HR = 2. 397, P = 0. 016）, number of lymph nodes metastases （χ^2 = 11. 423, HR = 1. 567, P = 0. 001 ）, and MTV （χ^2 = 3. 872, HR = 2. 433, P = 0. 049 ） were significant predictors of survival. Multivariate analysis showed that MTV and AJCC stage were independent predictors of survival （χ^2 = 4. 525, HR = 1. 170, P = 0. 033 ; χ^2 = 4. 875, HR = 3. 071, P = 0. 027）. Kaplan-Meier survival curves revealed longer survival time of low-MTV group as compared to high-MTV group （ Log-rank, χ^2 = 4. 186, P = 0. 041 ）. Conclusion MTV on ^18 F- FDG PET/CT may be an independent prognostic factor in patients with esophageal cancer.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2011年第6期378-381,共4页
Chinese Journal of Nuclear Medicine
