摘要
目的:观察体部伽玛刀联合化疗治疗不能手术或拒绝手术的局部晚期(WHO分期Ⅲa、Ⅲb)非小细胞肺癌(non-small cell lung cancer,NSCLC)的疗效和不良反应。方法:将2006年8月到2009年2月期间,我院治疗的110例符合入选条件的局部晚期NSCLC患者随机分成治疗组和对照组。治疗组:体部伽玛刀加化疗。体部伽玛刀治疗:单次处方剂量50%等剂量曲线为350cGy-400cGy,每天一次,共12-14次,总剂量49Gy-56Gy。化疗:采用紫杉醇+顺铂方案,于伽玛刀治疗后1周左右开始,平均4个周期。对照组:常规放射治疗加化疗。采用60Co体外照射,放射剂量为50Gy-54Gy,180cGy-200cGy/次,每周5次,5-6周完成,化疗方案同治疗组。结果:治疗组:有效率为81.94%,1年、2年生存率分别为65.28%、47.22%,放射性肺炎发生率3.57%。对照组:有效率为63.16%,1年、2年生存率分别为39.47%、23.68%,放射性肺炎发生率16.67%,差异有统计学意义。结论:体部伽玛刀联合化疗对不能手术或拒绝手术的局部晚期NSCLC有效,不良反应轻微。
Objective：To evaluate the therapeutic effect and radiation reactions of body gamma knife in the treatment for inoperable or refused surgery locally advanced non-small cell lung cancer patients.Methods： From August 2006 to February 2009,110 patients with locally advanced non-small cell lung cancer were randomly divided into treatment group and control group in this study.Treatment group： body-gamma knife combined with chemotherapy.Body-gamma knife with schema-periphery dose 350cGy-400cGy per fraction（50% dose line）,12-14 fractions was carried out,at a total dose of 49Gy-56Gy.Chemotherapy with TP regimen 4 cycles was performed one week after the body-gamma knife radiotherapy.Control group： Conventional radiotherapy combined with chemotherapy.dose 180cGy-200cGy per fraction,25 fractions was carried out,at a total dose of 50Gy-54Gy.Chemotherapy with the same as treatment group＇s.Results： Effective rate,1-year survival and 2-year survival of the treatment group is 65.28%,47.22%,and the control group was 63.16%,39.47%,23.68%,radiation pneumonitis incidence was 3.57% and 16.67%,respectively.Conclusion： Body-gamma knife combined with chemotherapy may have short-term therapeutic effects for the inoperable or refused surgery local advanced non-small cell lung cancer with mild toxicity.
出处
《现代肿瘤医学》
CAS
2011年第12期2434-2437,共4页
Journal of Modern Oncology
基金
四川省科技厅科研基金资助项目(编号:2009SZ0132)
关键词
体部伽玛刀
局部晚期非小细胞肺癌
化疗
body gamma knife
local advanced
non-small cell lung cancer
chemotherapy
