摘要
目的通过对 CD3^+表皮内 T 细胞在人体正常皮肤及瘢痕组织中的分布密度的研究,阐明表皮内 T 细咆对表皮细胞发育分化、分裂再生的影响。方法利用组织学和免疫组织化学法,观察表皮内 T 细胞在表皮组织中的分布。结果正常表皮组织中存在有少量 CD3^+表皮内 T 细胞,增生性瘢痕组织中可见较正常组织数量多的 CD3^+表皮内 T 细胞,表皮细胞增生活跃,萎缩性瘢痕组织中未发现有 CD3^+表皮内 T 细胞存在,表皮细胞层平坦。结论正常皮肤组织和瘢痕组织中CD3^+表皮内 T 细胞的分布情况不同,提示 CD3^+表皮内 T 细胞可能与表皮细胞的发育分化、分裂再生有关,CD3^+表皮内 T 细胞在表皮组织中的正常分布,对维持表皮组织的正常形态可能具有特殊意义。
Objective To investigate the CD3/TCR - bearing T cell in the epidermis and explore the influence of the dendritic epidermal T cells on regeneration and differentiation of epidermal cells.Meth- otis The CD3/TCR-bearing T cells in epidermis of human skin and cicatrix were examined by means of histomorphology and immunohistochemistry.Results It was found that the density of CD3/TCR-bearing T cells in human skin and scar tissue had great dissimilarity.CD3^+ dendritic epidermal T cells increased in hyperplastic scar.Such result was not observed in atrophic scar.Conclusion Our findings indicate CD3^+ dendritic epidermal T cells regulate the generation and differentiation of epidermal cells.CD3^+ dendritic epidermal T cells may play an important role in the maintenance of the morphology of epidermal tissue.
基金
本课题受国家自然基金资助(编号:39700144)
关键词
表皮内T细胞
瘢痕
形态学
Dendritic epidermal Tcell(DETC)
Cicatrix
