摘要
阿尔茨海默症是一种以进行性记忆和认知功能障碍为特征的神经退行性疾病,严重威胁着人类的生活与健康。针对其发病的多机制、多因素特点,近来提出的多靶点治疗策略成为了研究热点,而且报道了大量多靶点小分子抑制剂的设计与合成。本文重点对多靶点小分子乙酰胆碱酯酶抑制剂的研究进展进行综述。
Alzheimer＇s disease （AD） is a progressive and degenerative neurological disorder characterized by loss of cognition and memory, and has been a serious public health issue in the world. Because of AD sharing multi-factorial pathogenic mechanism, much attention has been paid to the multi-target therapy and lots of multi-target agents were designed and synthesized. Herein, the multi-target small molecular inhibitors for treatment of AD have been reviewed.
出处
《中国药物化学杂志》
CAS
CSCD
2011年第6期442-449,共8页
Chinese Journal of Medicinal Chemistry
基金
国家自然科学基金项目(90813011)
关键词
多靶点
小分子
阿尔茨海默症
综述
multi-target
small molecular
Alzheimer＇s disease
review
