摘要
目的了解我院金黄色葡萄球菌临床分离株对抗菌药物的耐药性及感染现状，以指导临床医生更科学合理用药。方法收集我院2009年11月-2011年9月间住院及门诊患者的标本，对分离出的108株金黄色葡萄球菌进行药敏试验。结果对甲氧西林耐药的金黄色葡萄球菌（MRSA）有76株，占70．4％；对甲氧西林敏感的金黄色葡萄球菌（MSSA）有32株，占29．6％。菌株主要分离于痰液／咽拭子，占42．6％；其次是分离于脓液／创面，占36．1％；其他的菌株分离于阴道分泌物、血液、尿液和精液，占21．3％。金黄色葡萄球菌中MRSA对16种抗菌药物的耐药率最高的是青霉素和苯唑西林，均为100．0％，而MSSA仅对青霉素的耐药率较高，达83．2％，对其余15种药物的耐药率都低于50％。万古霉素、呋喃妥因、替考拉宁耐药率在两者均为0。结论甲氧西林敏感金黄色葡萄球菌除了青霉素外对大多数的抗菌药物有较好的敏感性，而耐甲氧西林金黄色葡萄球菌的检出率仍然很高且多为多药耐药性。
Objective To instruct clinicians to prescribe medications more logically by investigating the antibiotic resistance and current infection status of staphylococcus aureus isolates. Methods Drug sensitivity testing was conducted in 108 staphylococcus aureus stains isolated from our hospital during the period of November 2009 to September 2011. Results 76 of 108 （70.4%） strains were methicillin-resistant staphylococcus aureus, while 32 （29.6%） were methicillin- sensitive. The strains （43.4%） were mainly isolated from sputum or throat swab, and 35.9% from pus or wound. 21.7% of the strains were isolated from vaginal discharges, blood, urine, and semen. The highest rate of staphylococcus aureus MRSA to 16 kinds of antimicrobial resistance was penicillin and oxacillin both acounted for 100.0%, and penicillin-resistant MSSA only the high rate for 83.2%, other 15 drug resistance rates were low at 50%.Vancomycin, nitrofurantoin, teicoplanin resistance rates in both were 0. Conclusions methicillin-sensitive Staphylococus aureus have good sensitivity for most of the antibiotics in addition to penicillin, and methicillin-resistant Staphyloccus aureus detection rate is still high and more for multi-drug resistance.
出处
《国际医药卫生导报》
2011年第24期3066-3069,共4页
International Medicine and Health Guidance News
关键词
金黄色葡萄球菌
抗菌药物
耐药
敏感
合理用药
Staphylococcus aureus
Antibacterial drugs
Drug resistance
Sensitive
Reasonable drug use
