摘要
目的 探讨血栓调节蛋白（ＴＭ） 及纤溶酶原活化物抑制剂（ＰＡＩ１） 与妊高征发病的关系。方法 选取１９９８ 年５ 月至１１ 月，在我院妇产科住院的妊高征患者７３ 例作为妊高征组，其中轻、中、重度妊高征患者分别为２６、２５ 和２２ 例。另选同期入院的正常孕妇２４ 例作为对照组。应用酶联免疫吸附试验和发色法，分别测定两组孕妇血浆中的ＴＭ 及ＰＡＩ１ 水平。结果 轻度妊高征患者血浆ＴＭ 为（４５－６９±１５－１５） μｇ／Ｌ，ＰＡＩ１ 为（２２－０６ ±１２－１３） ｋＵ／Ｌ。对照组ＴＭ 为（４０－１４ ±１５－８２） μｇ／Ｌ，ＰＡＩＩ为（１８－４０ ±９－７８） ｋＵ／Ｌ，两者比较，差异无显著性（ Ｐ＞ ０－０５） 。中度妊高征患者血浆ＴＭ 为（５２－７６ ±１３－９１） μｇ／Ｌ，ＰＡＩ１ 为（２５－７７±９－４５） ｋＵ／Ｌ，与对照组比较，差异有显著性（Ｐ＜０－０５）。重度妊高征患者血浆ＴＭ 为（６４－８６ ±１５－１６） μｇ／Ｌ，ＰＡＩＩ为（３０－７９ ±１１－６４） ｋＵ／Ｌ，与对照组比较，差异有非常显著性（Ｐ＜０－０１） 。结论 随着妊高征病情的逐渐加重，血浆中ＴＭ 及ＰＡＩ１ 的水平也逐渐升高；ＴＭ 及ＰＡＩ１的水平?
Objective TostudythecirculatinglevelsofThrombomodulin (TM) and Plasminogenactivator inhibitortype 1 (PAI 1) in women with pregnancy induced hypertention (PIH) and normal pregnant women- Methods Blood samples were withdrawnfrom 73 pregnantwomen,In which 25 mild PIH,26 moderate PIH,22 severe PIH were divided into study group,and 24 normotensive healthy pregnant women in theirthird trimester were controlgroup- The determination of TMwas measured by ELISAand PAI 1 by Colorimetric Assay methods- Results Circulationlevels of TMand PAI 1 were increased with increasing severity ofthe PIH- There were no significantdifferencesbetween groups of mild PIHand normalpregnancy (TM45-69 ±15-15 μg/Land 40-14 ± 15-82 μg/L,PAI 1 22-06 ±12-13 kU/Land 18-40 ±9-78 kU/Lrespectively)- The parameters significantly increasedin moderate (TM52-76 ±13-91 μg/L, PAI 1 25-77 ±9-45 kU/L) and severe PIH(TM64-84 ± 15-16 μg/L,PAI 1 30-79±11-64 kU/L) groups- Conclusions These results demonstrate thatthe endothelial cell damage anditsfunctional disturbance play a veryimportantrole inthe etiology of PIH-TMand PAI 1 may serveas clinical markersforthe assessmentofendothelialdamagein PIH-
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1999年第12期712-716,共5页
Chinese Journal of Obstetrics and Gynecology
关键词
妊娠高血压
血栓调节蛋白
纤溶酶原灭活剂
Pregnancy complications
cardiorasular
Hypertention
Plasminogenin activators
Thrombomodulin
