摘要
目的:观察并评价中药(溃结灌肠液)和美沙拉嗪气药灌肠对轻、中度活动期左半结肠及以上UC的临床疗效。方法:采用随机对照试验研究,将符合纳入标准的轻、中度活动期左半结肠及以上UC患者68例随机分为:治疗组33例,对照组35例。其中治疗组:溃结灌肠液80mL,气药灌肠(采用DGY-2型电脑灌肠仪),每天1次;对照组:美沙拉嗪颗粒剂2.0g,研成粉末加入生理盐水80mL,气药灌肠,每天1次;28天为1个疗程,分别记录并比较两组的临床症状、粪常规、结肠镜检查、DAI、临床缓解时间及不良反应。结果:完成试验者65例(治疗组33例,对照组32例),治疗组未见不良反应,对照组不良反应发生率(3/35)8.57%,治疗组与对照组在结肠镜下表现、DAI及临床疗效等方面差异无统计学意义。结论:中药(溃结灌肠液)气药灌肠治疗轻、中度活动期左半结肠及以上UC具有疗效确切、不良反应少等优点。
Objective：To observe and evaluate clinical effects of Qi-yao Enema with herbs Kuijie Guanchang Liquid or with Mesalazine for active mild to moderate left colon and above ulcerative colitis（UC）.Methods：A randomized controlled clinical trial was carried out.Sixty-eight patients with active mild to moderate UC in accordance with inclusion criteria were randomly divided into treatment group（n=33,herbs：Kuijie Guanchang Liquid,80mL,once per day） and control group（n=35,Mesalazine,2.0g,pulverize,add isotonic Na chloride 80ml,once per day）.They all underwent Qi-yao enema for 28 days.Their clinical and endoscopic manifestations,stool test,disease active index（DAI）,the time to clinical remission and adverse reaction were observed and compared.Results：65 patients completed the treatment（33 patients in treatment group,32 patients in control group）.The rate of adverse events in control group was 8.57%,no adverse events happened in treatment group.After 28 days treatment there were no statistical differences in terms of above data between treatment group and control group.Conclusion：Qi-yao Enema with herbs Kuijie Guanchang Liquid for active mild to moderate（Left colon and above） UC is effective,moreover,it induces less adverse effects.
出处
《辽宁中医杂志》
CAS
北大核心
2011年第12期2382-2384,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
江苏省中医药局科技基金资助项目(LZ09088)
南京市卫生局南京市医学科技发展基金资助项目(ZKX09038)
