摘要
目的：为探讨特发性血小板减少性紫癜（ＩＴＰ）脾切除自体脾移植治疗后的长期疗效及可能机制。方法：ＩＴＰ患者２４例，均行全脾切除自体脾移植术治疗，随访５～８年。结果：术后１周外周血小板计数明显升高，之后维持在正常范围；血清免疫球蛋白ＩｇＭ、ＩｇＧ和淋巴细胞转化率术后１ 月降低，之后稳定在正常水平。Ｂ型超声发现移植脾体积约５ ｃｍ ×６ ｃｍ 大小，γ－闪烁照相见移植再生脾具有吞噬功能。结论：提示自体脾移植既能治疗ＩＴＰ又保留了脾脏的功能，不会导致特发性血小板减少性紫癜的复发。
Objective: To study the long-term therapeutic efficacy of splenectom y and splenic autotransplantation forpatientswith idiopathie throm bocytopenicpurpura(ITP). Methods: 24casesofITPw ere treated with splenectomy and splenic autotransplantation and follow ed up for 60 to 96 m onths. Results: Therew as a significantincrease ofplateletcountone week postoperatively and a m arked decrease ofIgM, IgG and lym phocyte transform ation rate in the first m onth after operation. The platelet count, IgM, IgG and lym phocyte transform ation rate remained norm alin the follow -up period. The size ofthe transplanted spleen was 5 cm ×6 cm in allthe cases. Gam mascintigraphy dem onstrated that the splenic tissuespossessed phagocytic function. Conclusion: Our findings suggestthatautotransplantation ofsplenic tissue notonly treats ITPbutalso preserves a partofthe splenic functions. In addition, itw illnotinduce therecurrence ofITP.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1999年第12期930-932,共3页
Journal of Third Military Medical University
