摘要
目的：检测膀胱移行细胞癌中增殖细胞核抗原（ＰＣＮＡ）的表达，探讨与膀胱移行细胞癌预后的关系。方法：应用免疫组织化学技术，检测５５例膀胱移行细胞癌ＰＣＮＡ的表达。结果：５５例膀胱移行细胞癌中，ＰＣＮＡ标记指数随病理分级增高和肿瘤体积增大而增高，Ⅰ、Ⅱ、Ⅲ级间均有非常显著差异（Ｐ＜ ０．０１）。ＰＣＮＡ标记指数高表达者死亡率明显高于低表达者（Ｐ＜ ０．０１）。结论：ＰＣＮＡ是判断膀胱移行细胞癌恶性程度和预后的一个重要标志。
Objective: To study the relationship ofthe expression ofPCNA in bladdertransitionalcell carcinoma (TCC) with theprognosisofthem alignancy.Methods: Theexpression ofPCNAwasdeterm ined in 55 casesoftransitionalcellcarcinom aoftheurinary bladderw ith im m unohistochemistry. Results: In the 55 cases ofTCCof the urinary bladder, the expression ofPCNA was increased with the grading and the enlargem entofthe sizeofthem alignancy. Theexpression ratewassignificantly differentbetween grades Ⅰ and Ⅱand between grades Ⅱand Ⅲ(P< 0.01). The m ortality w as higher in the patients w ith higher expression rate ofPCNA than in those with lower expression rate. Conclusion: The expression rate of PCNAis a usefulindex to predicttheoutcom eofthe patients with bladderTCC.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1999年第12期902-903,共2页
Journal of Third Military Medical University
关键词
膀胱移行细胞癌
膀胱肿瘤
PCNA
预后
transitional cell carcinom a
im m unohistochemistry
proliferating cell nuclear antige
