摘要
目的：探讨骨肉瘤的性别、年龄、肿瘤部位、病理分型、肿瘤大小、核丝分裂像计数、ＤＮＡ图像分析、ＡｇＮＯＲｓ计数、ＰＣＮＡ分级、ＫｉＳ１ 分级、肥大细胞计数共１１个观察指标与骨肉瘤预后的关系。方法：单因素分析：Ｋａｐｌａｎ－Ｍｅｉｅｒ生存曲线法，Ｌｏｇ－ｒａｎｋ 检验法。多因素分析：多元线性回归法，多元逐步回归法。结果：经多元回归获得预后预测方程，其总Ｆ＝ １２．５７５，ｒ＝ ０．７１３４，Ｐ＜ ０．０００１。逐步回归检验显示６个明显的骨肉瘤预后影响因素，其作用强度依次为ＤＮＡ图像分析、ＡｇＮＯＲｓ计数、肿瘤大小、年龄、性别、肿瘤部位。结论：几项骨肉瘤细胞增殖活性指标对骨肉瘤预后的判断有一定的应用价值。
Objective: To analyze the prognostic significance ofsex,age,tum or site,tum or size,m itotic count,DNA contentAgNORscount,PCNAgrading,KiS1 grading and m astcellcountforosteosarcom a with multivariate regression. Methods: Univariate analysis including Kaplan-Meier survivalcurve and Log-rank testand m ultivariate analysisincluding m ultivariate linearregression and m ultivariatepartialregression w ere used.Results: A significantregression equation w as obtained as following:F= 12.575. r= 0.7134 and P< 0.0001. Partialregression revealed thatthe mostusefulprognosticfactorsforosteosarcom awereDNAploidy and DIvalue,tum orsize, tum or site,KiS1 grading and AgNORs count.Conclusion:Certain indices denoting the activity ofcellularproliferation ofosteosarcom a are usefulto itsprognosis.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1999年第12期893-895,共3页
Journal of Third Military Medical University
