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磷酸奥司他韦治疗甲型H1N1流行性感冒的临床疗效观察 被引量:6

Clinical Efficacy of Oseltamivir Phosphate in Treatment of Influenza A(H1N1) Diseases
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摘要 目的观察我院用磷酸奥司他韦治疗甲型H1N1流行性感冒的临床疗效和不良反应。方法对临床确诊的40例甲型H1N1流行性感冒患者均用磷酸奥司他韦进行治疗。结果除2例患者要求中途停止治疗外,38例患者均治愈出院,其中出现不良反应有3例,不良反应发生率为7.89%。结论磷酸奥司他韦对甲型H1N1流行性感冒有效,不良反应发生率相对较高。 Objective To observe clinical efficacy and adverse drug reactions(ADR)of Oseltamivir Phosphate in treatment of influenza A(H1N1) diseases in our hospital.Methods Forty cases of the influenza A(H1N1) diseases were treated with Oseltamivir Phosphate.Results Two cases the influenza A(H1N1) diseases stopped curing midway.Thirty--eigth cases of the influenza A(H1N1) diseases were cured,three cases have adverse reaction. The incident rate of adverse reaction was 7.89%.Conclusion Oseltamivir Phosphate was effictive in treatment of influenza A(HIN1)diseases,but the incident rate of adverse reaction was higher relatively.
出处 《中国卫生产业》 2011年第10X期39-40,共2页 China Health Industry
关键词 磷酸奥司他韦 甲型H1N1流行性感冒 Oseltamivir Phesphate Influenza A(H1N1)
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  • 1中华人民共和国卫生部.甲型H1N1流感诊疗方案(2009年第三版)[EB/OL].(2009-10-13)[2009-10-22].http://61.49.18.65/publicfiles/business/htmlfiles/mohyzs/s3586/200910/43111.htm.
  • 2Cao B,Li X-W,Mao Y,et al.Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China[J].N Engl J Med,2009,361 (26):2507-2517.
  • 3Moscona A.Global transmission of oseltamivir-resistant influenza[J].N Engl J Med,2009,360(10):953-956.
  • 4Garten R J,Davis C T,Russell C A,et al.Antigenic and genetic characteristics of swine-origin 2009 A (H1N1) influenza viruses circulating in humans[J].Science,2009,325 (5937):197-201.
  • 5Perez-Padilla R,de la Rosa-Zamboni D,Ponce de Leon S,et al.Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico[J].N Engl J Med,2009,361(7):680-689.
  • 6Treanor J J,Hayden F G,Vrooman P S,et al.Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza[J].JAMA,2000,283(8):1016-1024.
  • 7Nicholson K G,Aoki F Y,Osterhaus A D,et al.Efficacy and safety of the oseltamivir in treatment of acute influenza:a randornized controlled trial[J].Lancet,2000,355(9218):1845-1850.
  • 8Meier C R,Napalkov P N,Negmiileo Y,et al.Populationbased study on incidence,risk factors,clinical complications and drug utilization associated with influenza in the United Kingdom[J].Eur J Clin Microbiol Infect Dis,2000,19(11):834-842.
  • 9Kaiser L,Wat C,Mills T,et al.Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations[J].Arch Intern Med,2003,163(14):1667-1672.
  • 10Wetherall N T,Trivedi T,Zeller J,et al.Evaluation of neuraminidase enzyme assays using different substrates to measure susceptibility of influenza virus clinical isolates to neuraminidase inhibitors:report of the Neuraminidase Inhibitor Susceptibility Network[J].J Clin Microbiol,2003,41 (2):742-750.

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  • 1邓伟吾,李庆云,钟南山.流感季节磷酸奥司他韦治疗临床诊断的流感疑似患者的疗效与安全性研究[J].中华医学杂志,2004,84(24):2132-2136. 被引量:40
  • 2Treanor JJ,Hayden FG,Vrooman PS,et al. Efficacy and safetyof oral neuraminidase inhibitotor oseltamivir in treating acute influenza : arandomized controlled trial. US Oral Neuraminidase Study Group. . JAMA,2000,283(8):1016-1024.
  • 3Pappaioanou M. Highly pathogenic H5N1 avian influenza virus:cause of the next pandemic .Comp Immunol Microbiol Infect Dis,2009,32(4):287-300.
  • 4Von Itzstein M. Avian influenza virus, a very sticky situation.Curr Opin Che Biol,2008,12(1):102-108.
  • 5De Clereq E, Neyts J. Avian influenza A(H5N1)infection:targets and strategies For chemotherapeutic intervention. Trends PharmacolSci,2007,28(6):280-285.
  • 6Lewis D B. Avian flu to human influenza. Annu Rev Med,2006,57(11)::139-154.
  • 7齐攀. 禽流感患者服用达菲存活率较高. 医药经济报,2008-3-24.
  • 8Hayden F G, Fritz R, Lobo M C.Local and systemic cytokine responses during experimental human influenza A virus infection.Relation to syrup tom formation and host defense[J].Journal of Clinical Investigation, 2010, 32(3): 126-127.
  • 9Molecular Diagnostic Methods for Infectious Diseases.Approved Guideline- Second Edition.Clinical and Laboratory Standards Institute (Formerly NCCLS), MM3-A2, Vo126No.8, ISBN 1-56238-596-8.
  • 10李敬芳,朱慧芳.炎虎宁与利巴韦林剂量个体化治疗流行性感冒疗效对比观察[J].中国美容医学,2011,20(z4):105-106.

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