摘要
目的 研究化疗药物对原发性肝癌细胞的敏感性。方法 应用ＭＴＴ法及流式细胞仪，选择１７ 种化疗药物对２０ 例经手术切除的原发性肝癌标本进行化疗药物敏感性的检测。结果 对原发性肝癌细胞平均抑制率大于５０％ 的化疗药物为异环磷酰胺、氟脲嘧啶、ＶＭ２６（ 威猛） 、ＴＡＡ（泰素）、环磷酰胺及ＤＤＰ（ 顺铂） 。结论 根据联合化疗的原则，对于原发性肝癌患者建议选用的化疗方案为：以氟脲嘧啶为主、配合顺铂等其他一种或二种敏感的化疗药物。
Objective To study the sensitivity of the primary hepatic carcinoma to chemotherapeutic drugs.Methods Analyzed by MTT methods and Cytofluorometry,the sensitivity dection of 17 kinds of chemotherapeutic drugs to hepatic tumor cell which derived form 20 cases of patient with liver cancer was performed.Results After the determination,there are 6 chemical drugs,i.e.iCy,5 Fu,VM 26,TAA,Cy and DDP with the suppressionrate higher than 50% to the hepatic tumor cells.Conclusion Based on the chemotherapeutic schemes which consist of 5 Fu combination with another kind of sensitive chemotherapeutic drug such as DDP is of choice. Key word Hepatic carcinoma Chemotherapy Drug sensitivity
出处
《肝胆胰外科杂志》
CAS
1999年第4期174-176,共3页
Journal of Hepatopancreatobiliary Surgery
