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症状性基底动脉狭窄支架置入术后血清MMP-9与围手术期缺血性脑血管事件的关系 被引量：2

Association between serum matrix metalloproteinase-9 and ischemic cerebrovascular events in patients after brain artery stenting
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摘要 目的探讨血清基质金属蛋白酶-9(MMP-9)与症状性基底动脉狭窄支架置入术后围手术期缺血性脑血管事件的关系。方法测定42例基底动脉支架置入患者术后1d的外周血中血清MMP-9的水平,同时观察围手术期缺血性脑血管事件的发生情况。结果共有4例出现围手术期缺血性脑血管事件。血清MMP-9在围手术期出现缺血性脑血管事件者中高于未出现者(1106.71±237.21ng/ml vs 636.87.47±133.51ng/ml,P<0.01)。结论症状性基底动脉狭窄支架置入术后的MMP-9水平可能与围手术期缺血性脑血管事件危险增加有一定的相关性。 Objective To assess the association between levels of serum matrix metalloproteinase-9（MMP-9）and periprocedural ischemic cerebrovascular events（PICE）in patients undergoing verte-brobasilar artery stenting.Methods Serum MMP-9 were assayed in peripheral blood samples obtained 1d after stenting in 42 patients undergoing verte-brobasilar artery stenting,and the occurrence of PICE were observed as well.Results PICE presented in 4 cases.Levels of serum MMP-9 were higher in patients with PICE than in those without（1106.71±237.21ng/ml vs 636.87.47±133.51ng/ml,P0.01）.Conclusion High levels of serum MMP-9 1d after stenting may correlate with an increased risk of PICE in patients undergoing verte-brobasilar artery stenting.
作者 付胜奇 张淑玲 张道培 张洪涛 嵇朋
机构地区 郑州人民医院神经内科
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2011年第11期1010-1011,共2页 Journal of Apoplexy and Nervous Diseases
关键词 脑缺血 支架 MMP-9 Brain ischemia Stenting Matrix Metalloproteinase-9
分类号 R743 [医药卫生—神经病学与精神病学]
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参考文献12

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二级参考文献31

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共引文献75

同被引文献17

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中风与神经疾病杂志
2011年 第11期

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