摘要
目的:探讨脑卒中急性期Fib、PT、APTT、D-二聚体水平的变化及临床意义。方法:对82例急性脑梗死患者和66例急性脑出血患者,分别于发病后第1、3、7、14d同步测定血浆Fib、PT、APTT、D-二聚体水平,并与50例健康对照者进行比较。结果:脑卒中组第1、3、7dFib、D-二聚体水平均高于对照组(P<0.05),且二者呈强相关性。PT、APTT水平在脑卒中组及对照组中差异无统计学意义(P>0.05)。结论:脑卒中急性期与对照组比较Fib、D-二聚体均有增高,提示凝血功能异常可能与脑卒中的发生有关。血浆Fib、D-二聚体水平可作为预测脑卒中危险系数的指标之一,且还可作为评判脑卒中治疗疗效的指标之一。
Objective： To explore the changes of Fib、PT、APTT and D-dimer in acute stroke and their clinical significance. Methods： The levels of Fib、PT、APTT and D-dimer were investigated 82 cases acute cerebral infarctions and 66 cases acute cerebral hemorrhages on the days of 1 、3、7、14 d after getting ill, and the results were compared with the data from 50 cases healthy people. Rusults： The levels of Fib and D-dimer in the acute stroke group tested on the 1 、3、7 d were all higher than those of the contrastive group （P0.05）. A positive correlation was shown between Fib and D-dimer. The levels of PT and APTT in the acute stroke group had no obvious difference from those of the contrastive group （ P 0.05）. Conclusion： The levels of Fib and D-dimer in acute stroke group are all higher than those of the contrastive group. It indicates that coagulation disorder may be associated with the occurrence of acute stroke, and suggests that Fib and Ddimer will serve as one of the objective indicators for predictiing the stoke and evaluating the effectiveness of stoke therapy.
出处
《中国当代医药》
2011年第33期39-41,共3页
China Modern Medicine
关键词
脑出血
脑梗死
纤维蛋白原
D-二聚体
Cerebral hemorrhage
Cerebral infarction
Fibrinogen
D-dimer
