摘要
目的探讨视网膜母细胞瘤（RB）的病理形态特征及组织起源。方法回顾我院及广州军区总医院确诊为RB的病例共28例，并作NSE、S-100及GFAP免疫组织化学染色。结果光镜下28例RB中，未分化为主型10例，高分化为主型18例；NSE、S-100、GFAP在RB中的表达率分别为83．3％，44．4％，38．9％。结论RB光镜下大体上可分为高分化为主型和末分化为主型．菊形团、双极样细胞、坏死和钙化等病理改变具有一定的诊断价值。RB肿瘤细胞有向神经元和／或胶质细胞双向分化的能力，可能起源于神经外胚叶中具有多潜能的干细胞。
To explore the histopathology and histogenesis of retinoblastoma(RB). Mehtods 28 cases of RB onfiles were studied for histopathology, and l8 cases were also detected for the expression of NSE, S-100 and GFAP by immunohisto-chemistry.Results MIcroscopically,18 cases of RB were high-differentiated, othe 10 cases were low-differentiated. The ex-pression rates of NSE, S-100 and GFAP were 83.3%, 44.4%, and 38.9%, respectively.Conclusions 1.Histopathologi-cally, RB can be divided into two types: high or low differentiation type.The pathological change of ressetes,astrocytes andnecrosis are useful for the diagnosis of RB. 2. RB cells have the potent of neuron and/or glial cell differentiation, and may be o-riginatal from pluripotential stem cell of neural ectoderm.
出处
《诊断病理学杂志》
CSCD
1999年第4期207-208,I009,共3页
Chinese Journal of Diagnostic Pathology
