摘要
合成氟烷基酮的通用方法是将全氟烷基金属试剂与羰基类化合物反应。但对于ω位带有官能团的全氟烷基金属试剂的研究,唯一的例子是:
The metal-halogen exchange of ω-fluorosulfonylperfluoroalkyl iodide with EtMgBrresults in forming the corresponding perfluoroaldyl Grignard reagent(2). The fluorosulfonylgroup is not vulnerable to the attack of EtMgBr under the exchange reaction conditions. Theperfluoroalkyl Grignard does not undergo cyclization during its formation and can react withvarious carboxylic esters to give ω-fluorosulfonylperfluoroalkl ketones. Only 1, 2-additionproducts are obtained on treatment of 2 with α,β unsaturated aldehyde and ester.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
1990年第2期179-183,共5页
Chinese Journal of Organic Chemistry
关键词
格氏试剂
W氟砜基
氟烷基
制备
fluoroalkyl Grignard
fluorosulfonyl group
fluoroalkyl ketone
