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泛素-蛋白酶体通路与神经生长因子家族的肿瘤相关性研究进展 被引量：2

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摘要 泛素化是蛋白质翻译后重要修饰之一,是蛋白质降解信号,被泛素化修饰的蛋白质被蛋白酶识别从而被降解。近年来,人们通过对泛素化-蛋白酶体通路研究的深入,发现其是细胞内蛋白质选择性降解的主要途径,参与细胞凋亡、MHCⅠ类抗原的递呈、细胞周期以及细胞内信号传导等过程,对维持细胞的稳态具有极其重要的意义。
作者 刘晓君 王玉华
机构地区 河北医科大学第四医院肿瘤内科
出处 《实用癌症杂志》 2011年第6期665-666,672,共3页 The Practical Journal of Cancer
关键词 泛素-蛋白酶体通路(ubiquitin PROTEASOME pathway UPP) 泛素连接酶E3 神经生长因子及受体 肿瘤
分类号 R730.2 [医药卫生—肿瘤]
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参考文献28

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二级参考文献76

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实用癌症杂志
2011年 第6期

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