摘要
目的:研究注射用泮托拉唑钠治疗老年人非甾体类抗炎药(nonsteroidal anti-inflammatory drugs,NSAIDs)相关性消化性溃疡(peptic ulcer,PU)出血的疗效及安全。方法:选择我院2006年3月-2010年4月入院的80例65～85岁间服用NSAIDs1周内出现上消化道出血的老年患者,并经胃镜证实为PU出血,并随机分为泮托拉唑钠组(治疗组)40例和法莫替丁组(对照组)40例。治疗组泮托拉唑钠40 mg,q12 h静注,对照组法莫替丁20 mg,q12 h静注,疗程均为5 d。观察患者出血停止及不良反应发生情况。结果:治疗组和对照组治疗3 d,显效率分别为80%和25%(P<0.05),差异有统计学意义;治疗5 d总有效率分别为92.5%和60%(P>0.05),差异无统计学意义。结论:注射用泮托拉唑钠及法莫替丁对老年人NSAIDs相关性PU出血均有效,但前者疗效更为显著,提示注射用泮托拉唑钠可作为预防和治疗老年人NSAIDs相关性PU出血的主要药物。
OBJECTIVE To investigate the effects and safety of pantoprazole on the treatment of peptic ulcer bleeding related with nonsteroidal anti-inflammatory drugs（NSAIDs）. METHODS 80 patients（between 65 to 85 years old and were all given NSAIDs for 7 days） with peptic ulcer bleeding diagnosed by endoscope were randomly divided in two groups： pantoprazole group（treatment group） and famotidine group（control group）. The treatment group received pantoprazole 40 mg, q12 h, the control group received famotidine 20 mg,q12 h by intravenous drip for 5 days. RESULTS After 3 days of treatment the excellent rates were 80% in pantoprazole group and 25% in famotidine group （P〈0. 05）. After 5 days of treatments the total effective rates were 92. 5% in pantoprazole group and 60% in famotidine group（P〉0. 05）. CONCLUSION Pantoprazole has more distinguished therapeutic effect than famotidine in peptic ulcer bleeding related with NSAIDs in the aged.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2011年第23期1964-1966,共3页
Chinese Journal of Hospital Pharmacy
