摘要
目的观察复方甘草酸苷注射液联合咪唑斯汀治疗慢性荨麻疹的临床效果及安全性。方法选择140例慢性荨麻疹,随机分为观察组和对照组。观察组92例给予复方甘草酸苷注射液联合咪唑斯汀治疗,对照组仅给予咪唑斯汀治疗,观察两组临床疗效及不良反应情况。结果两组症状总积分治疗后均较治疗前明显降低,差异有统计学意义(P<0.01);但治疗后观察组症状总积分明显低于对照组,两组比较差异有统计学意义(P<0.05)。治疗4周后,总有效率观察组为86.96%,对照组为60.42%,两组比较差异亦有统计学意义(χ2=7.139,P<0.05)。两组不良反应发生率比较差异无统计学意义(χ2=0.872,P>0.05),程度均较轻,治疗结束后自行消退。结论复方甘草酸苷注射液联合咪唑斯汀治疗慢性荨麻疹具有疗效好、见效快、不良反应少等优点,是目前治疗慢性荨麻疹的一种较佳治疗方案。
Objective To investigate the clinical efficacy and safety of Compound Glycyrrhizin Injection combined with Mizolastine in treatment of chronic urticaria.Methods 140 patients with chronic urticaria were randomly divided into observation group and the control group,92 cases of the observation group were given Compound Glycyrrhizin Injection and Mizolastine combined treatment,the control group only received a single Mizolastine treatment.Clinical efficacy and adverse effects before and after treatment were observed.Results Total symptom scores of both groups after treatment were significantly lower than those before treatment with significant differences（P0.01）;the total symptom scores of the observation group after treatment was significantly lower than that of the control group,which was significantly different（P0.05）.4 weeks after treatment,the effective rate of the observation group was 86.96%,significantly higher than the 60.42% of the control group,and the difference was significant（χ2= 7.139,P0.05）;the two groups＇ adverse reactions were mild,and the withdrawal was self-limiting,and there was no significant difference among the two groups（χ2= 0.872,P0.05）.Conclusion To chronic urticaria,the Compound Glycyrrhizin Injection combined with Mizolastine is effective,with a higher efficacy rate and a lower rate of adverse reaction.
出处
《临床误诊误治》
2011年第11期19-21,共3页
Clinical Misdiagnosis & Mistherapy
关键词
荨麻疹
慢性病
复方甘草酸苷
咪唑斯汀
药物疗法
联合
Urticaria
Chronic disease
Compound glycyrrhizin
Mizolastine
Drug therapy
Combination
