摘要
通过Science Direct数据库查阅了近10年有关肾损伤标志物的报道,对肾小管损伤特异性标志物方面的文献进行了整理和分析。一些敏感性好、特异性高的肾小管损伤标志物已在实验研究和临床观察得到了部分验证,如肾损伤分子-1,肾损伤时在肾小管上皮细胞过度表达,对肾肿瘤、缺血性和肾毒性肾损伤的早期诊断敏感性好,且检测稳定性高;肝型脂肪酸结合蛋白,参与肾局部的脂质代谢,对肾近端小管的特异性很高,其尿液含量变化在多种类型的急性肾损伤早期评价中都具有重要价值;白介素-18作为诊断指标,敏感性和特异性均在90%以上,可将急性肾小管坏死从其他类型的肾疾病中区分出来,亦可预测肾损伤的发生和肾功能的恢复;中性粒细胞明胶酶相关脂质运载蛋白,常作为一个最早的表达产物在肾损伤时被检测到,其变化早于肌酐和其他标志物,有明显的时间优势。不同的标志物各具特点又都有不足,因此联合检测才能更大范围、更灵敏地评价肾损伤。
The reports concerned with renal injury markers in recent 10 years were consulted through Science Direct database,and literature related to specific markers of renal tubular injury were compiled and analyzed.Some biomarkers have been partially verified the good sensitivity and high specificity in experimental studies and clinical observations.For example,Kidney injury molecule-1,which would over express in the kidney injury in renal tubular epithelial cells,is sensitive to the early diagnosis of kidney cancer,ischemic and renal toxic renal injury,and detected with high stability.Liver-type fatty acid binding protein involved in local lipid metabolism of renal,with high specificity to renal proximal tubule.Its content in urine were of great value for early evaluation of various types of acute kidney injury.As a diagnostic indicator,sensitivity and specificity of Interleukin-18 were more than 90%.It could distinguish acute tubular necrosis from other types of kidney diseases,also predict the renal injury occurrence and renal function recovery.Neutrophil gelatinase-associated lipocalin was often detected as the first expressed product in the injury kidney,which changed earlier than creatinine and other markers,with obvious time advantage.All biomarkers have different characteristics and respective shortage.So joint detection were better to wider and sensitive evaluation of renal injury.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第23期279-284,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家重点基础研究发展计划(973)项目(2009CB522807)
国家"重大新药创制"科技重大专项项目(2009ZX09502-002)
