摘要
目的运用功能磁共振（fMRI）静息态低频振幅（ALFF）方法比较注意缺陷多动障碍（ADHD）儿童静息脑活动与正常儿童的差别；结合症状评分量表探讨ADHD症状严重程度与静息自发脑活动是否存在相关性。方法学龄期ADHD32例，年龄及受教育程度匹配的正常儿童30名，分别采集两组儿童的静息状态fMRI脑血氧水平依赖（BOLD）信号，ALFF处理两组BOLD图像，进行双样本t检验获取显著性激活脑区图（P〈0．01）。对ADHD组每个儿童症状评分量表（RS—IV）总分与提取的相应显著性脑区ALFF值进行相关分析获得相关显著脑区。结果ADHD与正常组比较，ALFF值减低脑区：右额上回（BA9，t=-4．61），左额上回内侧（BA10，t=-3．63），左额中回（BA46，t=-4．09）及左前扣带回（BA24，t=-4．02）。ALFF值增加脑区：左眶额叶内侧（BA11，t=3．52），右楔叶（t=3．93），右枕中回（BA19，t=3．82），右侧小脑（BA37，t=3．77），右颞中回（BA37，t=3．76），左旁中央小叶（BA6，t=3．77）。ADHD组ALFF与RS—IV总分相关显著脑区：左额上回内侧（P=0．009，r=0．492），右楔叶（P=0．024，r=0．433）。结论静息状态下ADHD的前额叶自发活动水平低下，某些功能相关脑区活动增强可作为补偿机制；左额叶及右楔叶的静息自发活动水平与ADHD症状严重程度呈正相关。
Objective To investigate the difference of the spontaneous neuronal activity between attention-deficit hyperactivity disorder （ADHD） and normal children with amplitude of low-frequency fluctuation （ALFF） of the resting-state fMRI, and to discuss the correlation between the activity level of brain and symptom severity. Methods Thirty-two children with ADHD of school age and thirty age-and gender-matched controls were experienced with resting-state fMRI scans while blood oxygenation level dependent （BOLD） signal was acquired to calculate the amplitude of low-frequency fluctuation （ALFF）. Linear correlations were performed between the aggregate score of RS-IV and ALFF voxels in ADHD patients. Results Compared to the controls,the ADHD group exhibited decreased ALFF in right superior frontal gyrus （ BA9, t = - 4.61 ） , left superior medial frontal gyrus （ BA10, t = - 3.63 ） ,left mediate frontal （ BA46, t = - 4.09） , and left anterior eingulate cortex （ BA24, t = - 4. 02 ）. Meanwhile, it showed increased ALFF in the medial orbitofrontal cortex（ BA11, t = 3.52） , right cuneus gyrus （ t = 3.93 ）, right mediate occipital gyrus （ BAI 9, t = 3.82）, right cerebellum （ BA37, t = 3.77 ）, right mediate temporal gyms（ BA37, t = 3.76）, and left paracentral lobe （BA6, t = 3.77）. Altered ALFF in left superior medial frontal gyrus（P = 0.009, r = 0. 492）and the right euneus gyrus（P = 0. 024, r = 0.433 ） showed correlation with the aggregate score of RS-IV. Conclusion The spontaneous neuronal activity decreases in prefrontal cortex and increases in default mode network of ADHD group, the activity level of left prefrontal and right cuneus gyrus is positively correlated with symptom severity.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2011年第11期1002-1004,共3页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然基金资助项目（30870868）
关键词
注意缺陷多动障碍
静息态功能磁共振
低频振幅
症状评分
Attention deficit hyperactivity disorder
Resting-state functional magnetic resonance
Amplitude of low frequency fluctuation
Symptom score
