摘要
背景:基因技术联合干细胞植入治疗缺血性心脏病是继单纯干细胞治疗后的一大热点。目的:归纳总结基因修饰及干细胞治疗缺血性心脏病的研究现状。方法:计算机检索PubMed数据库中2000-01/2010-12期间相关文献,检索词为"genetic,stem cells,myocardial infarction"。选择与基因修饰联合干细胞治疗缺血性心脏病密切相关的的29篇文献进行综述。结果与结论:不同功能的基因对干细胞和/或周围环境进行修饰,改善干细胞及相应的性状,以提高移植干细胞的存活能力、促进缺血心肌及周围的血管新生、改善血管顺应性、增加与宿主心肌细胞的耦联、增强干细胞趋化归巢作用等,提高干细胞治疗缺血性心脏病的效果。随着基因技术与干细胞应用的不断发展,可能在缺血性心脏的临床治疗方面得到广泛的应用。
BACKGROUND： Genetically modified stem cells in treating ischemic heart disease is one of the focus area of cardiovascular research after the simple stem cells therapy, and it may open a new and useful way for treatment of ischemic heart disease. OBJECTIVE： To summarize the situation and progression about gene-modified stem cell therapy for ischemic heart disease at present. METHODS： Databases of CNKI and Pubmed （2000-01/2010-12） were used to search the related articles about gene-modified stem cell therapy of ischemic heart disease. The keywords were ＂genetic, stem cells, myocardial infarction＂. Finally, 29 articles related to genetically modified stem cells in treating ischemic heart disease were included. RESULTS AND CONCLUSION： For the purpose of improving stem cells effect on ischemic heart disease, different gene are applied to modify stem cells and their surrounding environment to improve the stem cells and the corresponding traits in order to promote transplanted stem cell viability, promote angiogenesis of myocardial ischemia and peripheral tissues, improve vascular compliance, increase the coupling with host cardiomyocytes, and enhance the homing of stem cells. With the development of gene technology and stem cell application, stem cell therapy may be widely used in clinical treatment of ischemic heart disease.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第40期7577-7580,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
新疆维吾尔自治区自然科学基金项目(2009211B20)
新疆维吾尔自治区教育部科学技术研究重点项目(209137)~~
