摘要
背景:干细胞移植治疗糖尿病足主要是根据干细胞可以在体内分化为血管内皮细胞和平滑肌细胞,分泌大量的促血管生成因子,形成新生血管的原理,改善和恢复下肢血流,达到治疗下肢缺血的目的。目的:总结近年来在糖尿病足发病机制和干细胞治疗方面取得的研究进展。方法:应用计算机检索1997-01/2011-01PubMed、Science direct数据库相关文章,检索词为"diabetic foot,lower limb ischemia, neuropathy, microangiopathy, macroangiopathy,stem cell therapy",并限定文章语言种类为English。分类筛选符合研究目的文献进行评价,最终纳入32篇文献。结果与结论:通过对不同来源干细胞生物学特性及移植效果的比较,得出脐带、脂肪组织、羊水来源间充质干细胞,取材方便,分离容易,增殖能力强,具有与骨髓干细胞相似的生物学特性,有望成为干细胞移植的理想选择。还需要对干细胞的生物学特性、移植剂量、时机、疗程和致瘤性等方面进行研究。
BACKGROUND： Stem cell transplantation for treatment of diabetic foot is mainly based on in vivo differentiation of stem cells to vascular endothelial cells and smooth muscle cells to secrete a large amount of angiogenic factors to form new blood vessels, improves and restores lower limb blood flow to achieve the purpose of treating lower limb ischemia. OBJECTIVE： To summarize recent research achievements at pathogenesis of diabetic foot and stem cell transplantation and provide direction for further research. METHODS： We retrieved PubMed and Sciencedirect Databases for relevant articles published from January 1997 to January 2011.The key words were＂diabeticfoot,lowerlimbischemia,neuropathy,microangiopathy,macroangiopathy,stem cell therapy＂in English.Finally,a total of 32 articles were included.RESULTS AND CONCLUSION：Mesenchymal stem cells from umbilical cord,fat tissue and amniotic fluid may be optimal choices by comparison of biological characteristics and transplantation effect with different sources of stem cells.The characteristics are easy to be obtained and separated,and possessing strong proliferative capacity.We need a further research with biological characteristics of stem cells,transplantation dose,opportunity,course and tumorigenicity,etc.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第40期7560-7564,共5页
Journal of Clinical Rehabilitative Tissue Engineering Research
