摘要
目的:研究黏膜下层早期胃癌淋巴结转移的预测因素.方法:回顾性分析解放军总医院1996-2010年手术治疗的290例黏膜下层早期胃癌中与淋巴结转移相关的临床病理资料.结果:黏膜下层早期胃癌淋巴结转移率为21.4%.单因素分析表明影响黏膜下层早期胃癌淋巴结转移的因素主要有肿瘤大小、组织学类型、浸润深度和脉管浸润.多因素分析显示肿瘤大小、组织学类型和脉管浸润与黏膜下层早期胃癌淋巴结转移独立相关.结论:黏膜下层早期胃癌淋巴结转移与肿瘤大小、组织学类型和脉管浸润因素有关.内镜治疗等微创治疗可考虑应用于肿瘤<2cm同时为分化型的黏膜下层早期胃癌中.
AIM：To analyze the predictive risk factors for lymph node metastasis in early gastric cancer with submucosal invasion.METHODS：The clinical data for 290 patients surgically treated for early gastric cancer with submucosal invasion between 1996 and 2010 were reviewed retrospectively.The clinicopathological variables predicting lymph node metastasis were evaluated.RESULTS：Lymph node metastasis was observed in 21.4% of patients included.Univariate analysis showed that tumor size,histologic type,depth of invasion and presence of vascular or lymphatic invasion were positively correlated with lymph node metastasis.Multivariate analyses revealed that tumor size（≥2 cm）,histologic type and vascular or lymphatic involvementwere independently related to lymph node metastasis.Histologic type was the strongest predictive factor for lymph node metastasis in early gastric cancer with submucosal invasion.CONCLUSION：Tumor size,histologic type and presence of vascular or lymphatic invasion are independent risk factors for lymph node metastasis in early gastric cancer with submucosal invasion.Minimally invasive treatment,such as endoscopic mucosal resection,may be possible in differentiated submucosal cancer of small size（2 cm）.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第28期2970-2973,共4页
World Chinese Journal of Digestology
关键词
早期胃癌
黏膜下
淋巴结转移
Early gastric carcinoma
Submucosal invasion
Lymph node metastasis
